Human iPS cell-derived sensory neurons can be infected by SARS-CoV-2

Anthony Flamier, Punam Bisht, Alexsia Richards, Danielle L. Tomasello, Rudolf Jaenisch

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

COVID-19 has impacted billions of people since 2019 and unfolded a major healthcare crisis. With an increasing number of deaths and the emergence of more transmissible variants, it is crucial to better understand the biology of the disease-causing virus, the SARS-CoV-2. Peripheral neuropathies appeared as a specific COVID-19 symptom occurring at later stages of the disease. In order to understand the impact of SARS-CoV-2 on the peripheral nervous system, we generated human sensory neurons from induced pluripotent stem cells that we infected with the SARS-CoV-2 strain WA1/2020 and the variants delta and omicron. Using single-cell RNA sequencing, we found that human sensory neurons can be infected by SARS-CoV-2 but are unable to produce infectious viruses. Our data indicate that sensory neurons can be infected by the original WA1/2020 strain of SARS-CoV-2 as well as the delta and omicron variants, yet infectability differs between the original strain and the variants.

Original languageEnglish
Article number107690
JournaliScience
Volume26
Issue number9
DOIs
StatePublished - 15 Sep 2023
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2023 The Authors

Keywords

  • Cellular neuroscience
  • Neuroscience
  • Virology

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