Human housekeeping genes are compact

Eli Eisenberg, Erez Y. Levanon

Research output: Contribution to journalShort surveypeer-review

550 Scopus citations


We identify a set of 575 human genes that are expressed in all conditions tested in a publicly available database of microarray results. Based on this common occurrence, the set is expected to be rich in 'housekeeping' genes, showing constitutive expression in all tissues. We compare selected aspects of their genomic structure with a set of background genes. We find that the introns, untranslated regions and coding sequences of the housekeeping genes are shorter, indicating a selection for compactness in these genes.

Original languageEnglish
Pages (from-to)362-365
Number of pages4
JournalTrends in Genetics
Issue number7
StatePublished - 1 Jul 2003
Externally publishedYes


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