Human Chorionic Gonadotropin and Related Peptides: Candidate Anti-Inflammatory Therapy in Early Stages of Sepsis

Sun Koo Yoo, Syed Faizan Mehdi, Suma Pusapati, Nimisha Mathur, Manasa Anipindi, Bruno Lunenfeld, Barbara Lowell, Huan Yang, Christine Noel Metz, Sawleha Arshi Khan, Derek Leroith, Jesse Roth

    Research output: Contribution to journalReview articlepeer-review

    5 Scopus citations

    Abstract

    Sepsis continues to be a major cause of morbidity, mortality, and post-recovery disability in patients with a wide range of non-infectious and infectious inflammatory disorders, including COVID-19. The clinical onset of sepsis is often marked by the explosive release into the extracellular fluids of a multiplicity of host-derived cytokines and other pro-inflammatory hormone-like messengers from endogenous sources (“cytokine storm”). In patients with sepsis, therapies to counter the pro-inflammatory torrent, even when administered early, typically fall short. The major focus of our proposed essay is to promote pre-clinical studies with hCG (human chorionic gonadotropin) as a potential anti-inflammatory therapy for sepsis.

    Original languageEnglish
    Article number714177
    JournalFrontiers in Immunology
    Volume12
    DOIs
    StatePublished - 13 Sep 2021

    Bibliographical note

    Publisher Copyright:
    © Copyright © 2021 Yoo, Mehdi, Pusapati, Mathur, Anipindi, Lunenfeld, Lowell, Yang, Metz, Khan, Leroith and Roth.

    Funding

    The authors declare that this study received philanthropic funding from Alan and Tatyana Forman through Altronix Inc. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article or the decision to submit it for publication.

    FundersFunder number
    Altronix Inc.

      Keywords

      • anti-inflammatory
      • cytokine storm
      • human chorionic gonadotrophic hormone (hCG)
      • inflammation
      • sepsis

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