Human γδ T lymphocytes are licensed for professional antigen presentation by interaction with opsonized target cells

Nourredine Himoudi, Daniel A. Morgenstern, Mengyong Yan, Bertrand Vernay, Luisa Saraiva, Yin Wu, Cyrille J. Cohen, Kenth Gustafsson, John Anderson

Research output: Contribution to journalArticlepeer-review

108 Scopus citations

Abstract

Activated human blood γδ T cells have also been previously demonstrated to behave as professional APCs, although the processes that control APC function have not been characterized. n this study, we show that the acquisition of potent APC function by human blood γδ T cells is achieved after physical interaction with an Ab-coated target cell, a process that we refer to as licensing. In cancer models, licensing of γδ T cells by tumor-reactive mAbs promotes the uptake of tumor Ags and professional presentation to tumor-reactive αβ T cells. We propose that licensing by Ab is a mechanism whereby the adaptive properties of γδ T cells are induced by their innate functions in a spatially and temporally controlled manner.

Original languageEnglish
Pages (from-to)1708-1716
Number of pages9
JournalJournal of Immunology
Volume188
Issue number4
DOIs
StatePublished - 15 Feb 2012

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