H2O2‐Diffusion Through Liposomes

Aryeh A. Frimer, Arthur Forman, Donald C. Borg

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


The toxicity of H2O2 suggests that it readily diffuses through cell membranes. The present paper demonstrates via a chromogenic peroxidase reaction that H2O2 can cross the lipid bilayer membrane without affecting the cell wall's integrity. In this demonstration, the chromogen ABTS was encapsulated with horseradish peroxidase into ovolecithin multilamellar liposomes. Upon the addition of dilute H2O2, the color was generated exclusively within the intact liposomes. Related results were observed with the AAP/DHBS chromogenic couple; however, this system is complicated by the small holes created by the phenol DHBS in the liposomal wall.

Original languageEnglish
Pages (from-to)442-445
Number of pages4
JournalIsrael Journal of Chemistry
Issue number4
StatePublished - 1983
Externally publishedYes


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