HSF1 renders NK cells too stressed to respond

Yael Gruper; Aviad Ben-Shmuel; Ruth Scherz-Shouval

doi:10.1038/s41556-024-01472-1

HSF1 renders NK cells too stressed to respond

Yael Gruper
, Aviad Ben-Shmuel
, Ruth Scherz-Shouval

Weizmann Institute of Science

Research output: Contribution to journal › Comment/debate

Abstract

The tumour microenvironment propagates stress responses in resident cells. In tumour-infiltrating natural killer (NK) cells, the HSF1 transcription factor binds to mediators of effector function, negatively regulating NK cytotoxicity. These findings provide important mechanistic insights that may enhance NK cell cancer therapy.

Original language	English
Pages (from-to)	1630-1631
Number of pages	2
Journal	Nature Cell Biology
Volume	26
Issue number	10
Early online date	2 Sep 2024
DOIs	https://doi.org/10.1038/s41556-024-01472-1
State	Published - Oct 2024
Externally published	Yes

Bibliographical note

Publisher Copyright:
© Springer Nature Limited 2024.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/s41556-024-01472-1

Cite this

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abstract = "The tumour microenvironment propagates stress responses in resident cells. In tumour-infiltrating natural killer (NK) cells, the HSF1 transcription factor binds to mediators of effector function, negatively regulating NK cytotoxicity. These findings provide important mechanistic insights that may enhance NK cell cancer therapy.",

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HSF1 renders NK cells too stressed to respond

Abstract

Bibliographical note

UN SDGs

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