TY - JOUR
T1 - HSF1 renders NK cells too stressed to respond
AU - Gruper, Yael
AU - Ben-Shmuel, Aviad
AU - Scherz-Shouval, Ruth
N1 - Publisher Copyright:
© Springer Nature Limited 2024.
PY - 2024/10
Y1 - 2024/10
N2 - The tumour microenvironment propagates stress responses in resident cells. In tumour-infiltrating natural killer (NK) cells, the HSF1 transcription factor binds to mediators of effector function, negatively regulating NK cytotoxicity. These findings provide important mechanistic insights that may enhance NK cell cancer therapy.
AB - The tumour microenvironment propagates stress responses in resident cells. In tumour-infiltrating natural killer (NK) cells, the HSF1 transcription factor binds to mediators of effector function, negatively regulating NK cytotoxicity. These findings provide important mechanistic insights that may enhance NK cell cancer therapy.
UR - http://www.scopus.com/inward/record.url?scp=85202963524&partnerID=8YFLogxK
U2 - 10.1038/s41556-024-01472-1
DO - 10.1038/s41556-024-01472-1
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C2 - 39223374
AN - SCOPUS:85202963524
SN - 1465-7392
JO - Nature Cell Biology
JF - Nature Cell Biology
ER -
