Hours of high-frequency stimulations reveal intracellular neuronal trends in vivo

H. Brama, A. Goldental, R. Vardi, E. A. Stern, I. Kanter

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The neuronal response to controlled stimulations in vivo has been classically estimated using a limited number of events. Here we show that hours of high-frequency stimulations and recordings of neurons in vivo reveal previously unknown response phases of neurons in the intact brain. Results indicate that for stimulation frequencies below a critical neuronal characteristic frequency, f c, response timings are stabilized to tens-of-microseconds accuracy. For stimulation frequencies exceeding f c the firing frequency is saturated and independent of the stimulation frequency, as a result of random neuronal response failures. This neuronal plasticity, previously shown in vitro, supports a robust mechanism for low firing rates on a network level.

Original languageEnglish
Article number46002
Number of pages8
Issue number4
StatePublished - 28 Dec 2016

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Copyright © EPLA, 2016.


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