Hot executive control and response to a stimulant in a double-blind randomized trial in children with ADHD

Jessica Yarmolovsky; Tamar Szwarc; Miguel Schwartz; Emanuel Tirosh; Ronny Geva

doi:10.1007/s00406-016-0683-8

Hot executive control and response to a stimulant in a double-blind randomized trial in children with ADHD

Jessica Yarmolovsky, Tamar Szwarc, Miguel Schwartz, Emanuel Tirosh, Ronny Geva

Department of Psychology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Attention deficit hyperactivity disorder (ADHD) is thought to involve an executive inhibitory control (IC) deficit, yet it is not clear if this is a general deficit affecting both cold and hot EC, and if methylphenidate (MPH) affects both systems in treated children. We explored this by using a Stroop-like task in children with ADHD as compared to controls, containing different types of emotional stimuli (six levels), and we investigated the role of intervention with MPH on IC as compared to placebo. Children with ADHD and controls (N = 40; 7–13 years old) were tested with a hot and cold Stroop-like task. This was followed by a double-blind placebo-controlled crossover trial of the effect of MPH on these skills. Children with ADHD showed a specific difficulty inhibiting their responses, particularly to hot, angry and frustration-inducing stimuli. Further, treatment with MPH was effective in reducing errors toward frustration-inducing stimuli as compared to placebo (p < .05, η² = .347), particularly with repeated exposure to the stimuli. Results indicate that children with ADHD experience executive control difficulties, particularly in hot negative emotional contexts. These emotion regulation difficulties are amenable to stimulant intervention.

Original language	English
Pages (from-to)	73-82
Number of pages	10
Journal	European Archives of Psychiatry and Clinical Neuroscience
Volume	267
Issue number	1
DOIs	https://doi.org/10.1007/s00406-016-0683-8
State	Published - 1 Feb 2017

Bibliographical note

Funding Information:
The authors thank the teams at the Developmental Neuropsychology Lab, Bar Ilan University, The Brain Research Center, Bar Ilan University and at Bnei Zion hospital, as well as the participating families. The study was supported by Infrastructure of the Science, Space and Technology office awarded to Prof. Ronny Geva.

Publisher Copyright:
© 2016, The Author(s).

Keywords

ADHD
Children
Executive control
Methylphenidate

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s00406-016-0683-8

Cite this

@article{be0c385d727e435c865953f350498feb,

title = "Hot executive control and response to a stimulant in a double-blind randomized trial in children with ADHD",

abstract = "Attention deficit hyperactivity disorder (ADHD) is thought to involve an executive inhibitory control (IC) deficit, yet it is not clear if this is a general deficit affecting both cold and hot EC, and if methylphenidate (MPH) affects both systems in treated children. We explored this by using a Stroop-like task in children with ADHD as compared to controls, containing different types of emotional stimuli (six levels), and we investigated the role of intervention with MPH on IC as compared to placebo. Children with ADHD and controls (N = 40; 7–13 years old) were tested with a hot and cold Stroop-like task. This was followed by a double-blind placebo-controlled crossover trial of the effect of MPH on these skills. Children with ADHD showed a specific difficulty inhibiting their responses, particularly to hot, angry and frustration-inducing stimuli. Further, treatment with MPH was effective in reducing errors toward frustration-inducing stimuli as compared to placebo (p < .05, η2 = .347), particularly with repeated exposure to the stimuli. Results indicate that children with ADHD experience executive control difficulties, particularly in hot negative emotional contexts. These emotion regulation difficulties are amenable to stimulant intervention.",

keywords = "ADHD, Children, Executive control, Methylphenidate",

author = "Jessica Yarmolovsky and Tamar Szwarc and Miguel Schwartz and Emanuel Tirosh and Ronny Geva",

note = "Publisher Copyright: {\textcopyright} 2016, The Author(s).",

year = "2017",

month = feb,

day = "1",

doi = "10.1007/s00406-016-0683-8",

language = "אנגלית",

volume = "267",

pages = "73--82",

journal = "European Archives of Psychiatry and Clinical Neuroscience",

issn = "0940-1334",

publisher = "D. Steinkopff-Verlag",

number = "1",

}

TY - JOUR

T1 - Hot executive control and response to a stimulant in a double-blind randomized trial in children with ADHD

AU - Yarmolovsky, Jessica

AU - Szwarc, Tamar

AU - Schwartz, Miguel

AU - Tirosh, Emanuel

AU - Geva, Ronny

PY - 2017/2/1

Y1 - 2017/2/1

N2 - Attention deficit hyperactivity disorder (ADHD) is thought to involve an executive inhibitory control (IC) deficit, yet it is not clear if this is a general deficit affecting both cold and hot EC, and if methylphenidate (MPH) affects both systems in treated children. We explored this by using a Stroop-like task in children with ADHD as compared to controls, containing different types of emotional stimuli (six levels), and we investigated the role of intervention with MPH on IC as compared to placebo. Children with ADHD and controls (N = 40; 7–13 years old) were tested with a hot and cold Stroop-like task. This was followed by a double-blind placebo-controlled crossover trial of the effect of MPH on these skills. Children with ADHD showed a specific difficulty inhibiting their responses, particularly to hot, angry and frustration-inducing stimuli. Further, treatment with MPH was effective in reducing errors toward frustration-inducing stimuli as compared to placebo (p < .05, η2 = .347), particularly with repeated exposure to the stimuli. Results indicate that children with ADHD experience executive control difficulties, particularly in hot negative emotional contexts. These emotion regulation difficulties are amenable to stimulant intervention.

AB - Attention deficit hyperactivity disorder (ADHD) is thought to involve an executive inhibitory control (IC) deficit, yet it is not clear if this is a general deficit affecting both cold and hot EC, and if methylphenidate (MPH) affects both systems in treated children. We explored this by using a Stroop-like task in children with ADHD as compared to controls, containing different types of emotional stimuli (six levels), and we investigated the role of intervention with MPH on IC as compared to placebo. Children with ADHD and controls (N = 40; 7–13 years old) were tested with a hot and cold Stroop-like task. This was followed by a double-blind placebo-controlled crossover trial of the effect of MPH on these skills. Children with ADHD showed a specific difficulty inhibiting their responses, particularly to hot, angry and frustration-inducing stimuli. Further, treatment with MPH was effective in reducing errors toward frustration-inducing stimuli as compared to placebo (p < .05, η2 = .347), particularly with repeated exposure to the stimuli. Results indicate that children with ADHD experience executive control difficulties, particularly in hot negative emotional contexts. These emotion regulation difficulties are amenable to stimulant intervention.

KW - ADHD

KW - Children

KW - Executive control

KW - Methylphenidate

UR - http://www.scopus.com/inward/record.url?scp=84960427811&partnerID=8YFLogxK

U2 - 10.1007/s00406-016-0683-8

DO - 10.1007/s00406-016-0683-8

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 26966012

SN - 0940-1334

VL - 267

SP - 73

EP - 82

JO - European Archives of Psychiatry and Clinical Neuroscience

JF - European Archives of Psychiatry and Clinical Neuroscience

IS - 1

ER -

Hot executive control and response to a stimulant in a double-blind randomized trial in children with ADHD

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this