Hormonology: A genomic perspective on hormonal research

Aaron J.W. Hsueh, P. Bouchard, I. Ben-Shlomo

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Recent advances in comparative genomics allow a new paradigm for hormonal research. At the centennial of the first use of the term hormone by Ernest Starling, we reflected on the changing approaches in elucidating hormonal signaling mechanisms and highlighted the inadequacy of the term endocrinology, implying remote activation, to describe the diverse modes of hormone actions. Several examples were presented to underscore the power of comparative genomics in the identification of new polypeptide hormones, receptors, and signaling pathways. We propose the use of the term hormonology to more accurately reflect the expanding boundaries of the discipline.

Original languageEnglish
Pages (from-to)333-338
Number of pages6
JournalJournal of Endocrinology
Volume187
Issue number3
DOIs
StatePublished - Dec 2005
Externally publishedYes

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