Hormonal therapy and pubertal development in boys with selective hypogonadotropic hypogonadism

T. Bistritzer; B. Lunenfeld; J. H. Passwell; R. Theodor

doi:10.1016/s0015-0282(16)60859-2

Hormonal therapy and pubertal development in boys with selective hypogonadotropic hypogonadism

T. Bistritzer
, B. Lunenfeld
, J. H. Passwell
, R. Theodor

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The authors have compared the effects of treatment with weekly injections of human chorionic gonadotropin (hCG) with those of monthly testosterone (T) injections in males with hypogonadotropic hypogonadism. There was no significant difference in pubertal development as measured by progression through the Tanner stages, final height, or bone age, with the two treatment regimens. The final testicular volume in patients treated with 5,000 U/week of hCG (14.0 ± 2.0 ml) was significantly greater than that in patients treated with 250-mg monthly T injections (4.3 ± 1.8 ml) (P < 0.01). This study shows that weekly injections of hCG are effective in achieving virilization in hypogonadotropic hypogonadic males, leading to a greater testicular growth than T preparations. Therefore, hCG treatment may have an advantageous effect on the eventual induction of fertility with human menopausal gonadotropin.

Original language	English
Pages (from-to)	302-306
Number of pages	5
Journal	Fertility and Sterility
Volume	52
Issue number	2
DOIs	https://doi.org/10.1016/s0015-0282(16)60859-2
State	Published - Aug 1989
Externally published	Yes

Bibliographical note

Funding Information:
Received August 17, 1984. Accepted September 4, 1985. Address requests for reprints to: Dr. C. Paul Swain, St. James' Hospital, Sarsfeld Road, London S.W. 12, United Kingdom. This study was supported by a grant from the Department of Health and Social Security. © 1986 by the American Gastroenterological Association 0016-5085/86/$3.50

Funding

* Supported by a grant from the Samuel Jared Kushnick Foundation. t Pediatric Endocrine Clinic. *R eprint requests and present address: Tzvy Bistritzer, M.D., Assaf Harofeh Medical Center, Department of Pediatrics, Zerifin, P.O.B. Beer Yaakov 70300, Israel. § Institute of Endocrinology. II Department of Pediatrics.

Funders
Samuel Jared Kushnick Foundation

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10.1016/s0015-0282(16)60859-2

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title = "Hormonal therapy and pubertal development in boys with selective hypogonadotropic hypogonadism",

abstract = "The authors have compared the effects of treatment with weekly injections of human chorionic gonadotropin (hCG) with those of monthly testosterone (T) injections in males with hypogonadotropic hypogonadism. There was no significant difference in pubertal development as measured by progression through the Tanner stages, final height, or bone age, with the two treatment regimens. The final testicular volume in patients treated with 5,000 U/week of hCG (14.0 ± 2.0 ml) was significantly greater than that in patients treated with 250-mg monthly T injections (4.3 ± 1.8 ml) (P < 0.01). This study shows that weekly injections of hCG are effective in achieving virilization in hypogonadotropic hypogonadic males, leading to a greater testicular growth than T preparations. Therefore, hCG treatment may have an advantageous effect on the eventual induction of fertility with human menopausal gonadotropin.",

author = "T. Bistritzer and B. Lunenfeld and Passwell, \{J. H.\} and R. Theodor",

note = "Funding Information: Received August 17, 1984. Accepted September 4, 1985. Address requests for reprints to: Dr. C. Paul Swain, St. James' Hospital, Sarsfeld Road, London S.W. 12, United Kingdom. This study was supported by a grant from the Department of Health and Social Security. {\textcopyright} 1986 by the American Gastroenterological Association 0016-5085/86/\$3.50",

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AU - Theodor, R.

N1 - Funding Information: Received August 17, 1984. Accepted September 4, 1985. Address requests for reprints to: Dr. C. Paul Swain, St. James' Hospital, Sarsfeld Road, London S.W. 12, United Kingdom. This study was supported by a grant from the Department of Health and Social Security. © 1986 by the American Gastroenterological Association 0016-5085/86/$3.50

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N2 - The authors have compared the effects of treatment with weekly injections of human chorionic gonadotropin (hCG) with those of monthly testosterone (T) injections in males with hypogonadotropic hypogonadism. There was no significant difference in pubertal development as measured by progression through the Tanner stages, final height, or bone age, with the two treatment regimens. The final testicular volume in patients treated with 5,000 U/week of hCG (14.0 ± 2.0 ml) was significantly greater than that in patients treated with 250-mg monthly T injections (4.3 ± 1.8 ml) (P < 0.01). This study shows that weekly injections of hCG are effective in achieving virilization in hypogonadotropic hypogonadic males, leading to a greater testicular growth than T preparations. Therefore, hCG treatment may have an advantageous effect on the eventual induction of fertility with human menopausal gonadotropin.

AB - The authors have compared the effects of treatment with weekly injections of human chorionic gonadotropin (hCG) with those of monthly testosterone (T) injections in males with hypogonadotropic hypogonadism. There was no significant difference in pubertal development as measured by progression through the Tanner stages, final height, or bone age, with the two treatment regimens. The final testicular volume in patients treated with 5,000 U/week of hCG (14.0 ± 2.0 ml) was significantly greater than that in patients treated with 250-mg monthly T injections (4.3 ± 1.8 ml) (P < 0.01). This study shows that weekly injections of hCG are effective in achieving virilization in hypogonadotropic hypogonadic males, leading to a greater testicular growth than T preparations. Therefore, hCG treatment may have an advantageous effect on the eventual induction of fertility with human menopausal gonadotropin.

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Hormonal therapy and pubertal development in boys with selective hypogonadotropic hypogonadism

Abstract

Bibliographical note

Funding

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