Hormonal Dependence of the First Spermatogenic Wave in the Mouse

R. Weissenberg, A. Eshkol, B. Lunenfeld

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Antiserum to rat gonadotropins (arG) has been proved capable of binding homologous luteinizing hormone (LH) and follicle stimulating hormone (FSH) in vitro and mouse LH and FSH in vivo. The administration of arG did not evoke antibody production. The physiological role of endogenous gonadotrophins during neonatal life was studied by administration of this antiserum to groups of newborn male mice. Daily injection of arG from birth up to the age of 100 days inhibited markedly weight increase of testes and accessory glands. Histological evaluation of the testes of such treated animals revealed that spermatogenesis up to the stage of pachytene spermatocytes can proceed in the absence of endogenous gonadotropins; however, no spermatids were formed and the number of cells that developed in the hormone-deprived animals was significantly lower than in the normal animal. Substitution treatment with exogenous FSH permitted the formation of a small number of spermatids, but completion of spermatogenesis was obtained only with combined LH and FSH treatment.

Original languageEnglish
Pages (from-to)135-140
Number of pages6
JournalArchives of Andrology
Volume9
Issue number2
DOIs
StatePublished - Sep 1982
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgments: This research was supported in part by agrant of the World Health Organization, Special Program of Research, Development and Research Training in Human Reproduction, to the Institute of Endocrinology serving as a WHO Collaborating Center for Fertility Promoting Agents. The hMG was kindly provided by Istituto Farmacologico Serono, Roma.

Keywords

  • Anti-rat gonadotropins (arG)
  • Infancy; Mouse
  • Spermatogenesis

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