TY - JOUR
T1 - HIV-1 dynamics in vivo
T2 - Virion clearance rate, infected cell life-span, and viral generation time
AU - Perelson, Alan S.
AU - Neumann, Avidan U.
AU - Markowitz, Martin
AU - Leonard, John M.
AU - Ho, David D.
PY - 1996/3/15
Y1 - 1996/3/15
N2 - A new mathematical model was used to analyze a detailed set of human immunodeficiency virus-type 1 (HIV-1) viral load data collected from five infected individuals after the administration of a potent inhibitor of HIV-I protease. Productively infected cells were estimated to have, on average, a life-span of 2.2 days (half-life t(1/2) = 1.6 days), and plasma virions were estimated to have a mean life-span of 0.3 days (t(1/2) = 0.24 days). The estimated average total HIV-I production was 10.3 x 109 virions per day, which is substantially greater than previous minimum estimates. The results also suggest that the minimum duration of the HIV-I life cycle in vivo is 1.2 days on average, and that the average HIV-I generation time - defined as the time from release of a virion until it infects another cell and causes the release of a new generation of viral particles - is 2.6 days. These findings on viral dynamics provide not only a kinetic picture of HIV-1 pathogenesis, but also theoretical principles to guide the development of treatment strategies.
AB - A new mathematical model was used to analyze a detailed set of human immunodeficiency virus-type 1 (HIV-1) viral load data collected from five infected individuals after the administration of a potent inhibitor of HIV-I protease. Productively infected cells were estimated to have, on average, a life-span of 2.2 days (half-life t(1/2) = 1.6 days), and plasma virions were estimated to have a mean life-span of 0.3 days (t(1/2) = 0.24 days). The estimated average total HIV-I production was 10.3 x 109 virions per day, which is substantially greater than previous minimum estimates. The results also suggest that the minimum duration of the HIV-I life cycle in vivo is 1.2 days on average, and that the average HIV-I generation time - defined as the time from release of a virion until it infects another cell and causes the release of a new generation of viral particles - is 2.6 days. These findings on viral dynamics provide not only a kinetic picture of HIV-1 pathogenesis, but also theoretical principles to guide the development of treatment strategies.
UR - http://www.scopus.com/inward/record.url?scp=0029967721&partnerID=8YFLogxK
U2 - 10.1126/science.271.5255.1582
DO - 10.1126/science.271.5255.1582
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C2 - 8599114
AN - SCOPUS:0029967721
SN - 0036-8075
VL - 271
SP - 1582
EP - 1586
JO - Science
JF - Science
IS - 5255
ER -
