Heart failure (HF) in which the blood supply does not match the body's needs, affects 10% of the population over 65 years old. The protein kinase C (PKC) family of kinases has a key role in normal and disease states. Here we discuss the role of PKC in HF and focus on the use of specific PKC regulators to identify the mechanism leading to this pathology and potential leads for therapeutics.
|Journal||Drug Discovery Today: Disease Mechanisms|
|State||Published - Jun 2010|
Bibliographical noteFunding Information:
We are grateful to Dr Marie-Helene Disatnik for helpful discussions and Dr Suresh Palaniyandi for consultation in this studies; the work was supported by the National Institutes of Health Grants NIH AA11147, HL52141 and HL76670 to D.M.-R.