Highly specific modulators of protein kinase C localization: Applications to heart failure

Nir Qvit, Daria Mochly-Rosen

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Heart failure (HF) in which the blood supply does not match the body's needs, affects 10% of the population over 65 years old. The protein kinase C (PKC) family of kinases has a key role in normal and disease states. Here we discuss the role of PKC in HF and focus on the use of specific PKC regulators to identify the mechanism leading to this pathology and potential leads for therapeutics.

Original languageEnglish
Pages (from-to)e87-e93
JournalDrug Discovery Today: Disease Mechanisms
Volume7
Issue number2
DOIs
StatePublished - Jun 2010
Externally publishedYes

Bibliographical note

Funding Information:
We are grateful to Dr Marie-Helene Disatnik for helpful discussions and Dr Suresh Palaniyandi for consultation in this studies; the work was supported by the National Institutes of Health Grants NIH AA11147, HL52141 and HL76670 to D.M.-R.

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