High-resolution VSDI retinotopic mapping via a DLP-based projection system

Adi Gross; Nadav H. Ivzan; Nairouz Farah; Yossi Mandel

doi:10.1364/BOE.10.005117

High-resolution VSDI retinotopic mapping via a DLP-based projection system

Adi Gross, Nadav H. Ivzan, Nairouz Farah, Yossi Mandel

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

High-resolution recording of visual cortex activity is an important tool for vision research. Using a customized digital mirror device (DMD) - based system equipped with retinal imaging, we projected visual stimuli directly on the rat retina and recorded cortical responses by voltage-sensitive dye imaging. We obtained robust cortical responses and generated high-resolution retinotopic maps at an unprecedented retinal resolution of 4.6 degrees in the field of view, while further distinguishing between normal and pathological retinal areas. This system is a useful tool for studying the cortical response to localized retinal stimulation and may shed light on various cortical plasticity processes.

Original language	English
Pages (from-to)	5117-5129
Number of pages	13
Journal	Biomedical Optics Express
Volume	10
Issue number	10
DOIs	https://doi.org/10.1364/BOE.10.005117
State	Published - 1 Oct 2019

Bibliographical note

Publisher Copyright:
© 2019 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

Funding

H2020 European Research Council (755748); Ministry of Defense (933640); United States-Israel Binational Science Foundation (2013259); Israel Science Foundation (157-16). The authors would like to thank Dr. Sharon Gilaie-Dotan and Prof. Amiram Grinvald for useful discussions and Mr. Dov Fridman for technical help.

Funders	Funder number
Horizon 2020 Framework Programme
H2020 European Research Council	755748
United States-Israel Binational Science Foundation	2013259
Israel Science Foundation	157-16
Ministry of Defense	933640

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10.1364/BOE.10.005117

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High-resolution VSDI retinotopic mapping via a DLP-based projection system

Abstract

Bibliographical note

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