High prevalence of activated protein C resistance due to factor V Leiden mutation in cases of intrauterine fetal death

H. Rothbart, G. Ohel, J. Younis, N. Lanir, B. Brenner

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Objective: To test a possible association between activated protein C resistance and intrauterine fetal death. Methods: The activated protein C anticoagulant activity and factor V R506Q mutation were assessed in 14 nonpregnant women with a history of intrauterine fetal death and 14 healthy controls. Results: Four women in the study group were heterozygotes for the factor V mutation and none of the controls. The mean activated protein C activity of the study group was statistically significantly lower than that of the controls (P = 0.013). Conclusion: Resistance to activated protein C activity may be of etiologic importance in some cases of intrauterine fetal death.

Original languageEnglish
Pages (from-to)228-230
Number of pages3
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume8
Issue number5
DOIs
StatePublished - 1999
Externally publishedYes

Keywords

  • Activated protein C resistance
  • Factor V mutation
  • Intrauterine fetal death

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