Abstract
Objective: To test a possible association between activated protein C resistance and intrauterine fetal death. Methods: The activated protein C anticoagulant activity and factor V R506Q mutation were assessed in 14 nonpregnant women with a history of intrauterine fetal death and 14 healthy controls. Results: Four women in the study group were heterozygotes for the factor V mutation and none of the controls. The mean activated protein C activity of the study group was statistically significantly lower than that of the controls (P = 0.013). Conclusion: Resistance to activated protein C activity may be of etiologic importance in some cases of intrauterine fetal death.
Original language | English |
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Pages (from-to) | 228-230 |
Number of pages | 3 |
Journal | Journal of Maternal-Fetal and Neonatal Medicine |
Volume | 8 |
Issue number | 5 |
DOIs | |
State | Published - 1999 |
Externally published | Yes |
Keywords
- Activated protein C resistance
- Factor V mutation
- Intrauterine fetal death