High-Intensity Functional Training: Molecular Mechanisms and Benefits

Tavor Ben-Zeev, Eitan Okun

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


High-intensity interval training (HIIT) and strength exercise are known to improve health markers, such as cardiovascular health, metabolic health, and cognitive function, as well as to reduce all-cause mortality. High-Intensity Functional Training (HIFT) is a training paradigm derived from both HIIT and strength exercise to elicit greater muscle recruitment than repetitive aerobic exercises, thereby improving both cardiovascular fitness and strength parameters. Herein, we provide a focused review of the known molecular mechanisms that underlie the beneficial effects of HIFT on cardiovascular, metabolic, and cognitive functions.

Original languageEnglish
Pages (from-to)335-338
Number of pages4
JournalNeuroMolecular Medicine
Issue number3
Early online date1 Jan 2021
StatePublished - Sep 2021

Bibliographical note

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC part of Springer Nature.


  • Crossfit®
  • HIFT
  • HIIT
  • Mechanical tension
  • Resistance training
  • mTOR


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