High gamma activity distinguishes frontal cognitive control regions from adjacent cortical networks

Moataz Assem; Michael G. Hart; Pedro Coelho; Rafael Romero-Garcia; Alexa McDonald; Emma Woodberry; Robert C. Morris; Stephen J. Price; John Suckling; Thomas Santarius; John Duncan; Yaara Erez

doi:10.1016/j.cortex.2022.12.007

High gamma activity distinguishes frontal cognitive control regions from adjacent cortical networks

Moataz Assem, Michael G. Hart, Pedro Coelho, Rafael Romero-Garcia, Alexa McDonald, Emma Woodberry, Robert C. Morris, Stephen J. Price, John Suckling, Thomas Santarius, John Duncan, Yaara Erez

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Though the lateral frontal cortex is broadly implicated in cognitive control, functional MRI (fMRI) studies suggest fine-grained distinctions within this region. To examine this question electrophysiologically, we placed electrodes on the lateral frontal cortex in patients undergoing awake craniotomy for tumor resection. Patients performed verbal tasks with a manipulation of attentional switching, a canonical control demand. Power in the high gamma range (70–250 Hz) distinguished electrodes based on their location within a high-resolution fMRI network parcellation of the frontal lobe. Electrodes within the canonical fronto-parietal control network showed increased power in the switching condition, a result absent in electrodes within default mode, language and somato-motor networks. High gamma results contrasted with spatially distributed power decreases in the beta range (12–30 Hz). These results confirm the importance of fine-scale functional distinctions within the human frontal lobe, and pave the way for increased precision of functional mapping in tumor surgeries.

Original language	English
Pages (from-to)	286-298
Number of pages	13
Journal	Cortex
Volume	159
DOIs	https://doi.org/10.1016/j.cortex.2022.12.007
State	Published - Feb 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors

Funding

The Royal Society provided financial support in the form of a Royal Society Dorothy Hodgkin Research Fellowship to YE (DH130100). Cambridge Commonwealth European and International Trust provided financial support in the form of a Yousef Jameel scholarship to MA. Guarantors of Brain provided financial support in the form of a Post-Doctoral Fellowship award to RRG. The National Institute for Health Research (NIHR, UK) provided financial support in the form of a Clinician Scientist Award 35 to SJP (ref: NIHR/CS/009/011). The Brain Tumour Charity provided financial support in the form of a grant award to MGH (ref: RG86218). J. D was funded by a Medical Research Council grant (MC_UU_00005/6). This work was supported by the NIHR Cambridge Biomedical Research Centre (BRC-1215-20014) and NIHR Applied Research Centre. All the sponsors had no role in the design or conduct of this research. We thank Mallory Owen for help with administering and analyzing neuropsychological tests.

Funders	Funder number
International Trust
NIHR Applied Research Centre
Medical Research Council	MC_UU_00005/6
National Institute for Health and Care Research	NIHR/CS/009/011
Royal Society	DH130100
Brain Tumour Charity	RG86218
NIHR Cambridge Biomedical Research Centre	BRC-1215-20014

Keywords

Cognitive control
ECoG
Electrocorticography
Fronto-parietal
High gamma
Intracranial EEG
Intraoperative
fMRI
iEEG

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10.1016/j.cortex.2022.12.007

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title = "High gamma activity distinguishes frontal cognitive control regions from adjacent cortical networks",

abstract = "Though the lateral frontal cortex is broadly implicated in cognitive control, functional MRI (fMRI) studies suggest fine-grained distinctions within this region. To examine this question electrophysiologically, we placed electrodes on the lateral frontal cortex in patients undergoing awake craniotomy for tumor resection. Patients performed verbal tasks with a manipulation of attentional switching, a canonical control demand. Power in the high gamma range (70–250 Hz) distinguished electrodes based on their location within a high-resolution fMRI network parcellation of the frontal lobe. Electrodes within the canonical fronto-parietal control network showed increased power in the switching condition, a result absent in electrodes within default mode, language and somato-motor networks. High gamma results contrasted with spatially distributed power decreases in the beta range (12–30 Hz). These results confirm the importance of fine-scale functional distinctions within the human frontal lobe, and pave the way for increased precision of functional mapping in tumor surgeries.",

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note = "Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = feb,

doi = "10.1016/j.cortex.2022.12.007",

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AU - Hart, Michael G.

AU - Coelho, Pedro

AU - Romero-Garcia, Rafael

AU - McDonald, Alexa

AU - Woodberry, Emma

AU - Morris, Robert C.

AU - Price, Stephen J.

AU - Suckling, John

AU - Santarius, Thomas

AU - Duncan, John

AU - Erez, Yaara

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N2 - Though the lateral frontal cortex is broadly implicated in cognitive control, functional MRI (fMRI) studies suggest fine-grained distinctions within this region. To examine this question electrophysiologically, we placed electrodes on the lateral frontal cortex in patients undergoing awake craniotomy for tumor resection. Patients performed verbal tasks with a manipulation of attentional switching, a canonical control demand. Power in the high gamma range (70–250 Hz) distinguished electrodes based on their location within a high-resolution fMRI network parcellation of the frontal lobe. Electrodes within the canonical fronto-parietal control network showed increased power in the switching condition, a result absent in electrodes within default mode, language and somato-motor networks. High gamma results contrasted with spatially distributed power decreases in the beta range (12–30 Hz). These results confirm the importance of fine-scale functional distinctions within the human frontal lobe, and pave the way for increased precision of functional mapping in tumor surgeries.

AB - Though the lateral frontal cortex is broadly implicated in cognitive control, functional MRI (fMRI) studies suggest fine-grained distinctions within this region. To examine this question electrophysiologically, we placed electrodes on the lateral frontal cortex in patients undergoing awake craniotomy for tumor resection. Patients performed verbal tasks with a manipulation of attentional switching, a canonical control demand. Power in the high gamma range (70–250 Hz) distinguished electrodes based on their location within a high-resolution fMRI network parcellation of the frontal lobe. Electrodes within the canonical fronto-parietal control network showed increased power in the switching condition, a result absent in electrodes within default mode, language and somato-motor networks. High gamma results contrasted with spatially distributed power decreases in the beta range (12–30 Hz). These results confirm the importance of fine-scale functional distinctions within the human frontal lobe, and pave the way for increased precision of functional mapping in tumor surgeries.

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High gamma activity distinguishes frontal cognitive control regions from adjacent cortical networks

Abstract

Bibliographical note

Funding

Keywords

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