Abstract
This study aimed to examine the relation between sex steroid hormone fluctuations during the menstrual cycle and serum lipoproteins and their constituents. Serum was obtained in the early follicular, preovulatory, and mid-luteal phases from 18 young women. Ovulation was confirmed by estrogen and progesterone assays. High density lipoprotein cholesterol (HDL-C) was found to increase by 16% in the preovulatory phase, in comparison to the early follicular phase. Serum apolipoprotein-AI (Apo-AI) was elevated in the preovulatory and mid-luteal phases (14% and 19% respectively) in comparison to the early follicular phase. Total cholesterol, triglycerides, very low, and low density lipoprotein-cholesterol (VLDL-C and LDL-C) and apolipoprotein-B (Apo-B) serum levels did not change throughout the cycle. In the mid-luteal phase, the Apo-AI/HDL-C ratio was higher than in the other two phases, suggesting altered HDL composition during this phase. These results suggest that endogenous progesterone, unlike some synthetic progestogens, does not negate the beneficial effect of estrogen on serum lipoproteins.
Original language | English |
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Pages (from-to) | 253-257 |
Number of pages | 5 |
Journal | Gynecological Endocrinology |
Volume | 6 |
Issue number | 4 |
DOIs | |
State | Published - Dec 1992 |
Externally published | Yes |
Bibliographical note
Funding Information:This work was supported by a grant from the Chief Scientist’s Office, Ministry of Health, Israel.
Funding
This work was supported by a grant from the Chief Scientist’s Office, Ministry of Health, Israel.
Funders | Funder number |
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Chief Scientist’s Office | |
Ministry of Health, State of Israel |
Keywords
- Apolipoprotein-Al
- Apolipoprotein-B
- Serum Lipoproteins
- Sex Hormones