High-affinity 3H-imipramine binding in platelets of children and adolescents with major affective disorders

Moshe Rehavi; Ronit Weizman; Cynthia Carel; Alan Apter; Sam Tyano

doi:10.1016/0165-1781(84)90116-1

High-affinity ³H-imipramine binding in platelets of children and adolescents with major affective disorders

Moshe Rehavi, Ronit Weizman, Cynthia Carel, Alan Apter, Sam Tyano

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

High-affinity ³H-imipramine binding to platelet membranes was evaluated in 12 untreated children and adolescents aged 11-17 years who met the DSM-III criteria for major affective disorders. The affective patients were compared to 13 nonaffective subjects and 15 normal controls of similar ages. No significant difference in the maximal binding of ³H-imipramine (B_max) and K_d values could be found among the three groups. ³H-imipramine binding values failed to discriminate between patients with major depression and those with bipolar disorder, depressed type. No association between a positive family history of major affective disorders and ³H-imipramine binding values was detected.

Original language	English
Pages (from-to)	31-39
Number of pages	9
Journal	Psychiatry Research
Volume	13
Issue number	1
DOIs	https://doi.org/10.1016/0165-1781(84)90116-1
State	Published - Sep 1984
Externally published	Yes

Bibliographical note

Funding Information:
This research was supported in part by the Center for Absorption in of lmmigration Absorption, State of Israel.

Funding

This research was supported in part by the Center for Absorption in of lmmigration Absorption, State of Israel.

Funders	Funder number
Center for Absorption

Keywords

Major affective disorders
tricyclic antidepressants

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/0165-1781(84)90116-1

Cite this

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AU - Apter, Alan

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