High-affinity 3H-imipramine binding in platelets of children and adolescents with major affective disorders

Moshe Rehavi, Ronit Weizman, Cynthia Carel, Alan Apter, Sam Tyano

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

High-affinity 3H-imipramine binding to platelet membranes was evaluated in 12 untreated children and adolescents aged 11-17 years who met the DSM-III criteria for major affective disorders. The affective patients were compared to 13 nonaffective subjects and 15 normal controls of similar ages. No significant difference in the maximal binding of 3H-imipramine (Bmax) and Kd values could be found among the three groups. 3H-imipramine binding values failed to discriminate between patients with major depression and those with bipolar disorder, depressed type. No association between a positive family history of major affective disorders and 3H-imipramine binding values was detected.

Original languageEnglish
Pages (from-to)31-39
Number of pages9
JournalPsychiatry Research
Volume13
Issue number1
DOIs
StatePublished - Sep 1984
Externally publishedYes

Bibliographical note

Funding Information:
This research was supported in part by the Center for Absorption in of lmmigration Absorption, State of Israel.

Keywords

  • Major affective disorders
  • tricyclic antidepressants

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