High-affinity imipramine binding and serotonin uptake in platelets of eight adolescent and ten adult obsessive-compulsive patients

A. Weizman, M. Carmi, H. Hermesh, A. Shahar, A. Apter, S. Tyano, M. Rehavi

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97 Scopus citations

Abstract

The authors evaluated high-affinity [3H]imipramine binding and [3H]serotonin uptake to platelets in 8 adolescent and 10 adult patients who met DSM-III criteria for obsessive-compulsive disorder in comparison with those of normal control subjects of similar ages. The maximal binding of [3H]imipramine was significantly lower in adults and adolescents with obsessive-compulsive disorder than in the control subjects. No differences between groups in the affinity of [3H]imipramine to its binding sites or in serotonin uptake kinetic measures were detected. The lower density of [3H]imipramine binding sites in platelet membrane in patients with obsessive-compulsive disorder might implicate involvement of the serotonergic system or might represent an adaptive response to a chronic disease.

Original languageEnglish
Pages (from-to)335-339
Number of pages5
JournalAmerican Journal of Psychiatry
Volume143
Issue number3
DOIs
StatePublished - 1986

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