Heteroatom doped blue luminescent carbon dots as a nano-probe for targeted cell labeling and anticancer drug delivery vehicle

  • Poushali Das
  • , Sayan Ganguly
  • , Tarun Agarwal
  • , Pritiprasanna Maity
  • , Sabyasachi Ghosh
  • , Sumita Choudhary
  • , Subhashis Gangopadhyay
  • , Tapas Kumar Maiti
  • , Santanu Dhara
  • , Susanta Banerjee
  • , Narayan Chandra Das

Research output: Contribution to journalArticlepeer-review

117 Scopus citations

Abstract

Herein, a simple and efficient method to fabricate nitrogen and sulphur doped photoluminescent carbon dots (C-dots) has been judiciously developed for targeting cancer cells. Advancement in newfangled imaging tool for cancer cells is a vital and highly trustworthy strategy for cancer therapy. The fluorescent C-dots prepared from κ-carrageenan and folic acid can serve as an efficient cargo for cancer cell labeling expressing the folate receptor on their surface. The prepared C-dots unveiled good water solubility, excellent photostability, and biocompatibility. The C-dots played the role of nano-vehicle for anticancer drug capecitabine under different pH environments. Also, C-dots were applied as invisible marker and finger print recovery applications. The folate receptor in C-dots led to amazing targetability of cancer cells and which embraces a great promise in biomedical studies.

Original languageEnglish
Article number121860
JournalMaterials Chemistry and Physics
Volume237
DOIs
StatePublished - 1 Nov 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019

Keywords

  • Carbon dots
  • Cellular imaging
  • Drug delivery
  • Invisible marker
  • Photoluminescence

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