Heteroatom doped blue luminescent carbon dots as a nano-probe for targeted cell labeling and anticancer drug delivery vehicle

Poushali Das, Sayan Ganguly, Tarun Agarwal, Pritiprasanna Maity, Sabyasachi Ghosh, Sumita Choudhary, Subhashis Gangopadhyay, Tapas Kumar Maiti, Santanu Dhara, Susanta Banerjee, Narayan Chandra Das

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

Herein, a simple and efficient method to fabricate nitrogen and sulphur doped photoluminescent carbon dots (C-dots) has been judiciously developed for targeting cancer cells. Advancement in newfangled imaging tool for cancer cells is a vital and highly trustworthy strategy for cancer therapy. The fluorescent C-dots prepared from κ-carrageenan and folic acid can serve as an efficient cargo for cancer cell labeling expressing the folate receptor on their surface. The prepared C-dots unveiled good water solubility, excellent photostability, and biocompatibility. The C-dots played the role of nano-vehicle for anticancer drug capecitabine under different pH environments. Also, C-dots were applied as invisible marker and finger print recovery applications. The folate receptor in C-dots led to amazing targetability of cancer cells and which embraces a great promise in biomedical studies.

Original languageEnglish
Article number121860
JournalMaterials Chemistry and Physics
Volume237
DOIs
StatePublished - 1 Nov 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019

Keywords

  • Carbon dots
  • Cellular imaging
  • Drug delivery
  • Invisible marker
  • Photoluminescence

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