Hemin/G-quadruplexes as DNAzymes for the fluorescent detection of DNA, aptamer-thrombin complexes, and probing the activity of glucose oxidase

Eyal Golub, Ronit Freeman, Angelica Niazov, Itamar Willner

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Hemin/G-quadruplex catalyzes the H2O2-mediated oxidation of Amplex Red to the fluorescent product resorufin. This process is implemented to develop hairpin nucleic acid structures for the detection of DNA, to probe the catalytic activity of glucose oxidase, to use the thrombin-aptamer complex as a catalytic readout structure, and to quantitatively analyze telomere chain composition.

Original languageEnglish
Pages (from-to)4397-4401
Number of pages5
JournalThe Analyst
Volume136
Issue number21
DOIs
StatePublished - 7 Nov 2011
Externally publishedYes

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