Hearing impairment: A panoply of genes and functions

Amiel A. Dror; Karen B. Avraham

doi:10.1016/j.neuron.2010.10.011

Hearing impairment: A panoply of genes and functions

Amiel A. Dror, Karen B. Avraham

Tel Aviv University

Research output: Contribution to journal › Review article › peer-review

133 Scopus citations

Abstract

Research in the genetics of hearing and deafness has evolved rapidly over the past years, providing the molecular foundation for different aspects of the mechanism of hearing. Considered to be the most common sensory disorder, hearing impairment is genetically heterogeneous. The multitude of genes affected encode proteins associated with many different functions, encompassing overarching areas of research. These include, but are not limited to, developmental biology, cell biology, physiology, and neurobiology. In this review, we discuss the broad categories of genes involved in hearing and deafness. Particular attention is paid to a subgroup of genes associated with inner ear gene regulation, fluid homeostasis, junctional complex and tight junctions, synaptic transmission, and auditory pathways. Overall, studies in genetics have provided research scientists and clinicians with insight regarding practical implications for the hearing impaired, while heralding hope for future development of therapeutics.

Original language	English
Pages (from-to)	293-308
Number of pages	16
Journal	Neuron
Volume	68
Issue number	2
DOIs	https://doi.org/10.1016/j.neuron.2010.10.011
State	Published - 21 Oct 2010
Externally published	Yes

Bibliographical note

Funding Information:
Research on hereditary hearing loss in the Karen B. Avraham laboratory is supported by NIH grant R01DC005641 from the National Institute of Deafness and Communication Disorders, Israel Science Foundation (1486/07), the Israel Ministry of Health (MOH), and the European Commission FP6 Integrated Project Eumodic 037188.

Funding

Research on hereditary hearing loss in the Karen B. Avraham laboratory is supported by NIH grant R01DC005641 from the National Institute of Deafness and Communication Disorders, Israel Science Foundation (1486/07), the Israel Ministry of Health (MOH), and the European Commission FP6 Integrated Project Eumodic 037188.

Funders	Funder number
European Commission FP6	037188
National Institute of Deafness and Communication Disorders, Israel Science Foundation	1486/07
National Institutes of Health
National Institute on Deafness and Other Communication Disorders	R01DC005641
Ministry of Health -Singapore
Ministry of Health, State of Israel

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10.1016/j.neuron.2010.10.011

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abstract = "Research in the genetics of hearing and deafness has evolved rapidly over the past years, providing the molecular foundation for different aspects of the mechanism of hearing. Considered to be the most common sensory disorder, hearing impairment is genetically heterogeneous. The multitude of genes affected encode proteins associated with many different functions, encompassing overarching areas of research. These include, but are not limited to, developmental biology, cell biology, physiology, and neurobiology. In this review, we discuss the broad categories of genes involved in hearing and deafness. Particular attention is paid to a subgroup of genes associated with inner ear gene regulation, fluid homeostasis, junctional complex and tight junctions, synaptic transmission, and auditory pathways. Overall, studies in genetics have provided research scientists and clinicians with insight regarding practical implications for the hearing impaired, while heralding hope for future development of therapeutics.",

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Hearing impairment: A panoply of genes and functions

Abstract

Bibliographical note

Funding

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