Abstract
The MATRICS Consensus Cognitive Battery (MCCB) fills a significant need for a standardized battery of cognitive tests to use in clinical trials for schizophrenia in adults aged 20-59. A need remains, however, to develop norms for younger individuals, who also show elevated risks for schizophrenia. Toward this end, we assessed performance in healthy adolescents. Baseline MCCB, reading and IQ data were obtained from healthy controls (ages 12-19) participating in two concurrent NIMH-funded studies: North American Prodromal Longitudinal Study phase 2 (NAPLS-2; n = 126) and Boston Center for Intervention Development and Applied Research (CIDAR; n = 13). All MCCB tests were administered except the Managing Emotions subtest from the Mayer-Salovey-Caruso Emotional Intelligence Test. Data were collected from 8 sites across North America. MCCB scores were presented in four 2-year age cohorts as T-scores for each test and cognitive domain, and analyzed for effects of age and sex. Due to IQ differences between age-grouped subsamples, IQ served as a covariate in analyses. Overall and sex-based raw scores for individual MCCB tests are presented for each age-based cohort. Adolescents generally showed improvement with age in most MCCB cognitive domains, with the clearest linear trends in Attention/Vigilance and Working Memory. These control data show that healthy adolescence is a dynamic period for cognitive development that is marked by substantial improvement in MCCB performance through the 12-19 age range. They also provide healthy comparison raw scores to facilitate clinical evaluations of adolescents, including those at risk for developing psychiatric disorders such as schizophrenia-related conditions.
| Original language | English |
|---|---|
| Pages (from-to) | 106-113 |
| Number of pages | 8 |
| Journal | Schizophrenia Research |
| Volume | 172 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - 1 Apr 2016 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2016 Elsevier B.V.
Funding
National Institute of Mental Health grants (U01MH0818902 to T.D.C., U01MH081984 to J.M.A., P50MH066286 to C.E.B., U01MH082022 to K.S.C., U01MH081857 to B.A.C., U01MH082004 to D.O.P., U01MH081928 to L.J.S., U01MH081988 to E.F.W., U01MH066160 to S.W.W., P50MH080272 to R.W. M.) and the Commonwealth Research Center of the Massachusetts Department of Mental Health (SCDMH82101008006 to L.J.S.). This work was also conducted with support from Harvard Catalyst, The Harvard Clinical and Translational Science Center Harvard Catalyst Clinical Research Center at Beth Israel Deaconess Medical Center, A Harvard University Clinical and Translational Science Center Research Unit (National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health Award 1UL1 TR001102-01 financial contributions from Harvard University and its affiliated academic health care centers). The content is solely the responsibility of the authors and does not necessarily represent the official views of Harvard Catalyst, Harvard University and its affiliated academic health care centers, or the National Institutes of Health. We acknowledge and thank the study participants and their family members. We also thank the clinical, research assistant, and data management staff from the Boston CIDAR and NAPLS-2 studies, including Caitlin Bryant, Ann Cousins, Grace Francis, Molly Franz, Michelle Friedman-Yakoobian, Lauren Gibson, Andréa Gnong-Granato, Maria Hiraldo, Sarah Hornbach, Matcheri Keshavan, Kristy Klein, Grace Min, Elena Molokotos, Keira O'' Donovan, Corin Pilo, Janine Rodenhiser-Hill, Julia Schutt, Rachael Serur, Shannon Sorenson, Reka Szent-Imry, Alison Thomas, Chelsea Wakeham, and Joanne Wojcik. We are further grateful for the hard work of many research volunteers, including Devin Donohoe, Zach Feder, Max Feit, Elizabeth Haxton, Sylvia Khromina, Alexandra Oldershaw, Katharine O''Neal, Elizabeth Piazza, Julia Reading, Olivia Schanz, and Naomi Stapleton. Finally, we thank the data management staff at the University of Calgary, including Jean Addington and Lu Liu. National Institute of Mental Health grants (U01MH0818902 to T.D.C., U01MH081984 to J.M.A., P50MH066286 to C.E.B., U01MH082022 to K.S.C., U01MH081857 to B.A.C., U01MH082004 to D.O.P., U01MH081928 to L.J.S., U01MH081988 to E.F.W., U01MH066160 to S.W.W., P50MH080272 to R.W. M.) and the Commonwealth Research Center of the Massachusetts Department of Mental Health (SCDMH82101008006 to L.J.S.). This work was also conducted with support from Harvard Catalyst, The Harvard Clinical and Translational Science Center Harvard Catalyst Clinical Research Center at Beth Israel Deaconess Medical Center, A Harvard University Clinical and Translational Science Center Research Unit (National Center for Research Resources and the National Center for Advancing Translational Sciences, National Institutes of Health Award 1UL1 TR001102-01 financial contributions from Harvard University and its affiliated academic health care centers). The content is solely the responsibility of the authors and does not necessarily represent the official views of Harvard Catalyst, Harvard University and its affiliated academic health care centers, or the National Institutes of Health.
| Funders | Funder number |
|---|---|
| Commonwealth Research Center of the Massachusetts Department of Mental Health | SCDMH82101008006 |
| Harvard Clinical and Translational Science Center Harvard Catalyst Clinical Research Center | |
| Harvard University Clinical and Translational Science Center | |
| National Institutes of Health | 1UL1 TR001102-01 |
| National Institute of Mental Health | U01MH081984, P50MH066286, U01MH082004, U01MH0818902, U01MH082022, U01MH081928, P50MH080272, U01MH081988, U01MH066160, U01MH081857 |
| National Center for Advancing Translational Sciences | |
| Harvard University |
Keywords
- Adolescents
- Clinical high risk
- Cognition
- Healthy controls
- MATRICS Consensus Cognitive Battery
- Psychosis
- Schizophrenia
