HCAR1-Mediated l-Lactate Signaling Suppresses Microglial Phagocytosis

Raneen Nicola, Ravit Madar, Eitan Okun

Research output: Contribution to journalArticlepeer-review


Microglia, the primary brain-resident immune cells, protect the brain from various harmful pathogens, insulting and maintaining its homeostasis by phagocytosing extracellular particles. How microglia are metabolically regulated by their microenvironment remains largely elusive. Here, we investigated how extracellular lactate, which is abundant in the brain and dynamically changes in pathological states, affects microglial phagocytotic ability. We show that l-lactate reduces microglia phagocytic capacity in a Hydroxycarboxylic Acid Receptor 1 but not Monocarboxylate transporter 1-dependent manner. Our findings point to a potential role for extracellular lactate in suppressing the phagocytic activity of microglial cells in homeostasis and inflammatory conditions.

Original languageEnglish
Pages (from-to)399-404
Number of pages6
JournalNeuroMolecular Medicine
Issue number4
StatePublished - Dec 2022

Bibliographical note

Funding Information:
Funding was provided by Israel Science Foundation (Grant No. 387/21).

Funding Information:
This manuscript was edited by Yael Laure

Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.


  • Amyloid-beta
  • HCAR1
  • Lactate
  • Microglia
  • Phagocytosis


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