Haptoglobin phenotype as a predictive factor of mortality in diabetic haemodialysis patients

Zvi Burbea, Farid Nakhoul, Roaa Zoabi, Irit Hochberg, Nina S. Levy, Sidney Benchetrit, Joshua Weissgarten, David Tovbin, Aaron Knecht, Adrian Iaina, Michal Herman, Batya Kristal, Andrew P. Levy

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Introduction: The mortality rate in diabetic dialysis patients (DDPs) is over 15% per year, with the cause of death most often attributed to cardiovascular disease (CVD) or bacterial infection (sepsis). Identification of genetic markers predictive of early mortality would be useful in the evaluation of therapies for the reduction of mortality rate in this population. Haptoglobin (Hp) is a polymorphic protein which appears to confer differential susceptibility to bacterial infection and CVD. We therefore proposed that Hp phenotype can predict mortality in DDPs. Methods: We tested this hypothesis prospectively in a longitudinal study of 392 dialysis patients from eight medical centres in Israel. Hp was determined by polyacrylamide gel electrophoresis. Patients were followed for all-cause mortality over a 3-year period. Results: We found that Hp phenotype was a significant predictor of mortality in DDPs stratified by age. In diabetic individuals over 60 years of age there was a decrease in mortality associated with the Hp 1-1 phenotype (P = 0.03). However, in younger DDPs the Hp 2-2 phenotype was associated with a decreased mortality rate (P = 0.003). Conclusion: Hp phenotype may be useful in the risk stratification algorithm and management of DDPs.

Original languageEnglish
Pages (from-to)469-473
Number of pages5
JournalAnnals of Clinical Biochemistry
Volume41
Issue number6
DOIs
StatePublished - Nov 2004
Externally publishedYes

Bibliographical note

Funding Information:
Matti Rossi is a professor of information systems at Aalto University School of Economics. He has worked as a research fellow at Erasmus University, Rotterdam, visiting assistant professor at Georgia State University, Atlanta, and visiting researcher at Claremont Graduate University. He has been the principal investigator in several major research projects funded by the technological development center of Finland and Academy of Finland.

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