H blood group detection by the L-fucose binding lectin of the green marine alga Ulva lactuca

Nechama Gilboa-Garber; Rachel Citronbaum; Cyril Levene; Ruth Sela

doi:10.1016/0145-305x(88)90045-6

H blood group detection by the L-fucose binding lectin of the green marine alga Ulva lactuca

Nechama Gilboa-Garber, Rachel Citronbaum, Cyril Levene, Ruth Sela

The Mina and Everard Goodman Faculty of Life Sciences - at Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Extracts of the green marine alga Ulva lactuca collected along the seashore of Tel-Aviv exhibit hemagglutinating activity towards papain-treated human erythrocytes. This hemagglutinating activity was shown to be inhibited by L-fucose and EDTA, and to be relatively resistant to heating at 60°C, while sensitive to low pH. Like the lectin of Ulex europeus, the Ulva lectin exhibits blood group H specificity. It agglutinates most strongly erythrocytes of blood group 0(H) followed by B > A > AB. A₂ and A₂B erythrocytes are agglutinated by it considerably more strongly than A₁ and A₁B respectively. Bombay 0(hh) type erythrocytes are almost non-reactive. The lectin can be stored at -20°C for years.

Original language	English
Pages (from-to)	695-705
Number of pages	11
Journal	Developmental and Comparative Immunology
Volume	12
Issue number	4
DOIs	https://doi.org/10.1016/0145-305x(88)90045-6
State	Published - 1988

Bibliographical note

Funding Information:
This research was supported by a grant from Bar-Ilan University research authorities. The authors thank Mrs. D. Radin for the skilful printing of the manuscript.

Funding

This research was supported by a grant from Bar-Ilan University research authorities. The authors thank Mrs. D. Radin for the skilful printing of the manuscript.

Funders	Funder number
Bar-Ilan University

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0145-305x(88)90045-6

Cite this

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title = "H blood group detection by the L-fucose binding lectin of the green marine alga Ulva lactuca",

abstract = "Extracts of the green marine alga Ulva lactuca collected along the seashore of Tel-Aviv exhibit hemagglutinating activity towards papain-treated human erythrocytes. This hemagglutinating activity was shown to be inhibited by L-fucose and EDTA, and to be relatively resistant to heating at 60°C, while sensitive to low pH. Like the lectin of Ulex europeus, the Ulva lectin exhibits blood group H specificity. It agglutinates most strongly erythrocytes of blood group 0(H) followed by B > A > AB. A2 and A2B erythrocytes are agglutinated by it considerably more strongly than A1 and A1B respectively. Bombay 0(hh) type erythrocytes are almost non-reactive. The lectin can be stored at -20°C for years.",

author = "Nechama Gilboa-Garber and Rachel Citronbaum and Cyril Levene and Ruth Sela",

note = "Funding Information: This research was supported by a grant from Bar-Ilan University research authorities. The authors thank Mrs. D. Radin for the skilful printing of the manuscript.",

year = "1988",

doi = "10.1016/0145-305x(88)90045-6",

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T1 - H blood group detection by the L-fucose binding lectin of the green marine alga Ulva lactuca

AU - Gilboa-Garber, Nechama

AU - Citronbaum, Rachel

AU - Levene, Cyril

AU - Sela, Ruth

N1 - Funding Information: This research was supported by a grant from Bar-Ilan University research authorities. The authors thank Mrs. D. Radin for the skilful printing of the manuscript.

PY - 1988

Y1 - 1988

N2 - Extracts of the green marine alga Ulva lactuca collected along the seashore of Tel-Aviv exhibit hemagglutinating activity towards papain-treated human erythrocytes. This hemagglutinating activity was shown to be inhibited by L-fucose and EDTA, and to be relatively resistant to heating at 60°C, while sensitive to low pH. Like the lectin of Ulex europeus, the Ulva lectin exhibits blood group H specificity. It agglutinates most strongly erythrocytes of blood group 0(H) followed by B > A > AB. A2 and A2B erythrocytes are agglutinated by it considerably more strongly than A1 and A1B respectively. Bombay 0(hh) type erythrocytes are almost non-reactive. The lectin can be stored at -20°C for years.

AB - Extracts of the green marine alga Ulva lactuca collected along the seashore of Tel-Aviv exhibit hemagglutinating activity towards papain-treated human erythrocytes. This hemagglutinating activity was shown to be inhibited by L-fucose and EDTA, and to be relatively resistant to heating at 60°C, while sensitive to low pH. Like the lectin of Ulex europeus, the Ulva lectin exhibits blood group H specificity. It agglutinates most strongly erythrocytes of blood group 0(H) followed by B > A > AB. A2 and A2B erythrocytes are agglutinated by it considerably more strongly than A1 and A1B respectively. Bombay 0(hh) type erythrocytes are almost non-reactive. The lectin can be stored at -20°C for years.

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H blood group detection by the L-fucose binding lectin of the green marine alga Ulva lactuca

Abstract

Bibliographical note

Funding

UN SDGs

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