Growth hormone response to exercise in asthmatic and normal children

I. Amirav, R. J. Dowdeswell, M. Plit, V. R. Panz, B. I. Joffe, H. C. Seftel

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Maximal growth hormone (GH) increments following exercise were compared in asthmatic (n=14) and normal (n=8) children. Exercise, which consisted of 6 min ergometer cycling while breathing cold dry (CD) air, induced asthma in all asthmatic patients but not in normal subjects. Baseline plasma GH levels were similar in both groups. Following exercise, however, asthmatic patients had significantly higher mean GH increments than normal subjects (14.8 vs 4.9 ng/ml, P<0.025). To evaluate the possible role of bronchoconstriction in the GH response all subjects exercised again, this time while breathing warm humid (WH) air. Despite the absence of exercise-induced asthma (EIA) while breathing WH air, asthmatic patients still had significantly higher mean GH increments than normal subjects (9.2 vs 2.3 ng/ml, P<0.05). We conclude that some asthmatic children show excessive GH secretion after exercise regardless of inspired air conditions or the development of EIA.

Original languageEnglish
Pages (from-to)443-446
Number of pages4
JournalEuropean Journal of Pediatrics
Volume149
Issue number6
DOIs
StatePublished - Mar 1990
Externally publishedYes

Keywords

  • Asthmatic children
  • Exercise
  • Growth hormone

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