Group and site differences on the California Verbal Learning Test in persons with schizophrenia and their first-degree relatives: Findings from the Consortium on the Genetics of Schizophrenia (COGS)

William S. Stone; Anthony J. Giuliano; Ming T. Tsuang; David L. Braff; Kristin S. Cadenhead; Monica E. Calkins; Dorcas J. Dobie; Stephen V. Faraone; Robert Freedman; Michael F. Green; Tiffany A. Greenwood; Raquel E. Gur; Ruben C. Gur; Gregory A. Light; Jim Mintz; Keith H. Nuechterlein; Ann Olincy; Allen D. Radant; Andrea H. Roe; Nicholas J. Schork; Larry J. Siever; Jeremy M. Silverman; Neal R. Swerdlow; Alison R. Thomas; Debby W. Tsuang; Bruce I. Turetsky; Larry J. Seidman

doi:10.1016/j.schres.2011.01.005

Group and site differences on the California Verbal Learning Test in persons with schizophrenia and their first-degree relatives: Findings from the Consortium on the Genetics of Schizophrenia (COGS)

William S. Stone, Anthony J. Giuliano, Ming T. Tsuang, David L. Braff, Kristin S. Cadenhead, Monica E. Calkins, Dorcas J. Dobie, Stephen V. Faraone, Robert Freedman, Michael F. Green, Tiffany A. Greenwood, Raquel E. Gur, Ruben C. Gur, Gregory A. Light, Jim Mintz, Keith H. Nuechterlein, Ann Olincy, Allen D. Radant, Andrea H. Roe, Nicholas J. SchorkLarry J. Siever, Jeremy M. Silverman, Neal R. Swerdlow, Alison R. Thomas, Debby W. Tsuang, Bruce I. Turetsky, Larry J. Seidman

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Genetic studies of schizophrenia focus increasingly on putative endophenotypes because their genetic etiology may be simpler than clinical diagnosis. The Consortium on the Genetics of Schizophrenia (COGS), a multisite family study, aims to identify the genetic basis of several endophenotypes including verbal declarative memory (VDM), a neurocognitive function that shows robust impairment in schizophrenia. We present data on one type of measure of VDM, the California Verbal Learning Test, Second Edition (CVLT-II), in schizophrenia probands (n = 305), their full biological siblings (n = 449) and parents (n = 232), and in community comparison subjects (CCS; n = 509) across seven sites. Probands performed more poorly on each of five CVLT-II measures compared to related sibling and parent groups and CCS. Siblings and parents performed significantly worse than CCS on one measure (Discriminability), but with smaller effect sizes and less impairment than observed previously. The results raise questions about the homogeneity of VDM as an endophenotype, about methodological issues related to sampling, and about psychometric issues that impact the utility of the CVLT for detecting VDM deficits in nonpsychotic relatives of persons with schizophrenia.

Original language	English
Pages (from-to)	102-110
Number of pages	9
Journal	Schizophrenia Research
Volume	128
Issue number	1-3
DOIs	https://doi.org/10.1016/j.schres.2011.01.005
State	Published - May 2011
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by the NIMH through grants to Harvard University (RO1-MH065562), Mount Sinai School of Medicine (ROI-MH065554), University of California Los Angeles (RO1-MH65707), University of California San Diego (RO1-MH065571), University of Colorado (RO1-MH65588), University of Pennsylvania (RO1-MH65578) and the University of Washington (RO1-MH65558).

Keywords

Endophenotype
Schizophrenia
Verbal declarative memory

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.schres.2011.01.005

Cite this

Stone, W. S., Giuliano, A. J., Tsuang, M. T., Braff, D. L., Cadenhead, K. S., Calkins, M. E., Dobie, D. J., Faraone, S. V., Freedman, R., Green, M. F., Greenwood, T. A., Gur, R. E., Gur, R. C., Light, G. A., Mintz, J., Nuechterlein, K. H., Olincy, A., Radant, A. D., Roe, A. H., ... Seidman, L. J. (2011). Group and site differences on the California Verbal Learning Test in persons with schizophrenia and their first-degree relatives: Findings from the Consortium on the Genetics of Schizophrenia (COGS). Schizophrenia Research, 128(1-3), 102-110. https://doi.org/10.1016/j.schres.2011.01.005

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title = "Group and site differences on the California Verbal Learning Test in persons with schizophrenia and their first-degree relatives: Findings from the Consortium on the Genetics of Schizophrenia (COGS)",

abstract = "Genetic studies of schizophrenia focus increasingly on putative endophenotypes because their genetic etiology may be simpler than clinical diagnosis. The Consortium on the Genetics of Schizophrenia (COGS), a multisite family study, aims to identify the genetic basis of several endophenotypes including verbal declarative memory (VDM), a neurocognitive function that shows robust impairment in schizophrenia. We present data on one type of measure of VDM, the California Verbal Learning Test, Second Edition (CVLT-II), in schizophrenia probands (n = 305), their full biological siblings (n = 449) and parents (n = 232), and in community comparison subjects (CCS; n = 509) across seven sites. Probands performed more poorly on each of five CVLT-II measures compared to related sibling and parent groups and CCS. Siblings and parents performed significantly worse than CCS on one measure (Discriminability), but with smaller effect sizes and less impairment than observed previously. The results raise questions about the homogeneity of VDM as an endophenotype, about methodological issues related to sampling, and about psychometric issues that impact the utility of the CVLT for detecting VDM deficits in nonpsychotic relatives of persons with schizophrenia.",

keywords = "Endophenotype, Schizophrenia, Verbal declarative memory",

author = "Stone, {William S.} and Giuliano, {Anthony J.} and Tsuang, {Ming T.} and Braff, {David L.} and Cadenhead, {Kristin S.} and Calkins, {Monica E.} and Dobie, {Dorcas J.} and Faraone, {Stephen V.} and Robert Freedman and Green, {Michael F.} and Greenwood, {Tiffany A.} and Gur, {Raquel E.} and Gur, {Ruben C.} and Light, {Gregory A.} and Jim Mintz and Nuechterlein, {Keith H.} and Ann Olincy and Radant, {Allen D.} and Roe, {Andrea H.} and Schork, {Nicholas J.} and Siever, {Larry J.} and Silverman, {Jeremy M.} and Swerdlow, {Neal R.} and Thomas, {Alison R.} and Tsuang, {Debby W.} and Turetsky, {Bruce I.} and Seidman, {Larry J.}",

note = "Funding Information: This work was supported by the NIMH through grants to Harvard University (RO1-MH065562), Mount Sinai School of Medicine (ROI-MH065554), University of California Los Angeles (RO1-MH65707), University of California San Diego (RO1-MH065571), University of Colorado (RO1-MH65588), University of Pennsylvania (RO1-MH65578) and the University of Washington (RO1-MH65558). ",

year = "2011",

month = may,

doi = "10.1016/j.schres.2011.01.005",

language = "אנגלית",

volume = "128",

pages = "102--110",

journal = "Schizophrenia Research",

issn = "0920-9964",

publisher = "Elsevier B.V.",

number = "1-3",

}

Stone, WS, Giuliano, AJ, Tsuang, MT, Braff, DL, Cadenhead, KS, Calkins, ME, Dobie, DJ, Faraone, SV, Freedman, R, Green, MF, Greenwood, TA, Gur, RE, Gur, RC, Light, GA, Mintz, J, Nuechterlein, KH, Olincy, A, Radant, AD, Roe, AH, Schork, NJ, Siever, LJ, Silverman, JM, Swerdlow, NR, Thomas, AR, Tsuang, DW, Turetsky, BI & Seidman, LJ 2011, 'Group and site differences on the California Verbal Learning Test in persons with schizophrenia and their first-degree relatives: Findings from the Consortium on the Genetics of Schizophrenia (COGS)', Schizophrenia Research, vol. 128, no. 1-3, pp. 102-110. https://doi.org/10.1016/j.schres.2011.01.005

Group and site differences on the California Verbal Learning Test in persons with schizophrenia and their first-degree relatives: Findings from the Consortium on the Genetics of Schizophrenia (COGS). / Stone, William S.; Giuliano, Anthony J.; Tsuang, Ming T. et al.
In: Schizophrenia Research, Vol. 128, No. 1-3, 05.2011, p. 102-110.

Research output: Contribution to journal › Article › peer-review

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AU - Stone, William S.

AU - Giuliano, Anthony J.

AU - Tsuang, Ming T.

AU - Braff, David L.

AU - Cadenhead, Kristin S.

AU - Calkins, Monica E.

AU - Dobie, Dorcas J.

AU - Faraone, Stephen V.

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AU - Gur, Raquel E.

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AU - Light, Gregory A.

AU - Mintz, Jim

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AU - Olincy, Ann

AU - Radant, Allen D.

AU - Roe, Andrea H.

AU - Schork, Nicholas J.

AU - Siever, Larry J.

AU - Silverman, Jeremy M.

AU - Swerdlow, Neal R.

AU - Thomas, Alison R.

AU - Tsuang, Debby W.

AU - Turetsky, Bruce I.

AU - Seidman, Larry J.

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Group and site differences on the California Verbal Learning Test in persons with schizophrenia and their first-degree relatives: Findings from the Consortium on the Genetics of Schizophrenia (COGS)

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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