Graphene-Based Nanomaterials for Neuroengineering: Recent Advances and Future Prospective

Raj Kumar, Rossana Rauti, Denis Scaini, Merav Antman-Passig, Ohad Meshulam, Doron Naveh, Laura Ballerini, Orit Shefi

Research output: Contribution to journalReview articlepeer-review

18 Scopus citations


Graphene unique physicochemical properties made it prominent among other allotropic forms of carbon, in many areas of research and technological applications. Interestingly, in recent years, many studies exploited the use of graphene family nanomaterials (GNMs) for biomedical applications such as drug delivery, diagnostics, bioimaging, and tissue engineering research. GNMs are successfully used for the design of scaffolds for controlled induction of cell differentiation and tissue regeneration. Critically, it is important to identify the more appropriate nano/bio material interface sustaining cells differentiation and tissue regeneration enhancement. Specifically, this review is focussed on graphene-based scaffolds that endow physiochemical and biological properties suitable for a specific tissue, the nervous system, that links tightly morphological and electrical properties. Different strategies are reviewed to exploit GNMs for neuronal engineering and regeneration, material toxicity, and biocompatibility. Specifically, the potentiality for neuronal stem cells differentiation and subsequent neuronal network growth as well as the impact of electrical stimulation through GNM on cells is presented. The use of field effect transistor (FET) based on graphene for neuronal regeneration is described. This review concludes the important aspects to be controlled to make graphene a promising candidate for further advanced application in neuronal tissue engineering and biomedical use.

Original languageEnglish
Article number2104887
JournalAdvanced Functional Materials
Issue number46
StatePublished - 10 Nov 2021

Bibliographical note

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© 2021 Wiley-VCH GmbH.


  • nanomaterials
  • neuroengineering
  • neuron differentiation
  • neuron outgrowth
  • neuronal interfaces
  • neuronal tissue engineering


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