Graft polymerization of styryl bisphosphonate monomer onto polypropylene films for inhibition of biofilm formation

Hanna P. Steinmetz, Safra Rudnick-Glick, Michal Natan, Ehud Banin, Shlomo Margel

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


There has been increased concern during the past few decades over the role bacterial biofilms play in causing a variety of health problems, especially since they exhibit a high degree of resistance to antibiotics and are able to survive in hostile environments. Biofilms consist of bacterial aggregates enveloped by a self-produced matrix attached to the surface. Ca2+ ions promote the formation of biofilms, and enhance their stability, viscosity, and strength. Bisphosphonates exhibit a high affinity for Ca2+ ions, and may inhibit the formation of biofilms by acting as sequestering agents for Ca2+ ions. Although the antibacterial activity of bisphosphonates is well known, research into their anti-biofilm behavior is still in its early stages. In this study, we describe the synthesis of a new thin coating composed of poly(styryl bisphosphonate) grafted onto oxidized polypropylene films for anti-biofilm applications. This grafting process was performed by graft polymerization of styryl bisphosphonate vinylic monomer onto O2 plasma-treated polypropylene films. The surface modification of the polypropylene films was confirmed using surface measurements, including X-ray photoelectron spectroscopy, atomic force microscopy, and water contact angle goniometry. Significant inhibition of biofilm formation was achieved for both Gram-negative and Gram-positive bacteria.

Original languageEnglish
Pages (from-to)300-306
Number of pages7
JournalColloids and Surfaces B: Biointerfaces
StatePublished - 1 Nov 2016

Bibliographical note

Publisher Copyright:
© 2016 Elsevier B.V.


  • Biofilm
  • Bisphosphonate
  • Graft polymerization
  • O plasma treatment


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