Gossypol-cross-linked boronic acid-modified Hydrogels: A functional matrix for the controlled release of an anticancer drug

Vered Heleg-Shabtai, Ruth Aizen, Ron Orbach, Miguel Angel Aleman-Garcia, Itamar Willner

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Anticancer drug gossypol cross-links phenylboronic acid-modified acrylamide copolymer chains to form a hydrogel matrix. The hydrogel is dissociated in an acidic environment (pH 4.5), and its dissociation is enhanced in the presence of lactic acid (an α-hydroxy carboxylic acid) as compared to formic acid. The enhanced dissociation of the hydrogel by lactic acid is attributed to the effective separation of the boronate ester bridging groups through the formation of a stabilized complex between the boronic acid substituent and the lactic acid. Because lactic acid exists in cancer cells in elevated amounts and the cancer cells environment is acidic, the cross-linked hydrogel represents a stimuli-responsive matrix for the controlled release of gossypol. The functionality is demonstrated and characterized by rheology and other spectroscopic means.

Original languageEnglish
Pages (from-to)2237-2242
Number of pages6
JournalLangmuir
Volume31
Issue number7
DOIs
StatePublished - 24 Feb 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2015 American Chemical Society.

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