Good's buffer derived highly emissive carbon quantum dots: excellent biocompatible anticancer drug carrier

Aneeya K. Samantara; Santanu Maji; Arnab Ghosh; Bamaprasad Bag; Rupesh Dash; Bikash Kumar Jena

doi:10.1039/c6tb00081a

Good's buffer derived highly emissive carbon quantum dots: excellent biocompatible anticancer drug carrier

Aneeya K. Samantara, Santanu Maji, Arnab Ghosh, Bamaprasad Bag, Rupesh Dash, Bikash Kumar Jena

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Here, a facile one-step approach has been developed for the synthesis of carbon quantum dots (CQDs) from Good's buffer. The as-synthesized CQDs emit a bright greenish blue coloured fluorescence after exposure to a 365 nm UV-lamp illumination. The bright fluorescence nature of the CQDs has proven them to be excellent probes for cellular imaging. The CQDs are highly biocompatible in nature, which has been validated by an MTT assay test. The in vitro MTT assay demonstrates a more than 95% survival rate when HEK293 (human embryonic kidney) and H357 (human oral squamous carcinoma) cells were treated with CQDs. The low cytotoxicity of Good's buffer derived CQDs opens the door to biomedical applications. The anticancer drug doxorubicin (DOX) was successfully loaded on the CQDs and their delivery efficiency to the target cells via in vitro treatment of cancerous cells was explored. The CQDs supported DOX showed a higher killing rate of the cancer cells compared to bare DOX due to its ease of internalization and efficient pH-triggered release inside the cells.

Original language	English
Pages (from-to)	2412-2420
Number of pages	9
Journal	Journal of Materials Chemistry B
Volume	4
Issue number	14
DOIs	https://doi.org/10.1039/c6tb00081a
State	Published - 14 Apr 2016
Externally published	Yes

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry 2016.

Funding

Aneeya K. Samantara acknowledges CSIR for fellowship. Dr B. K. Jena is thankful to MNRE, New Delhi, India (No. 102/87/2011-NT), BRNS, Mumbai, India (No. 2013/37P/67/BRNS) and CSIR, New Delhi, India (Young Scientist Award Project-YSP-2/2013, P-81-113 and MLP-20, MULTIFUN (CSC-0101)) for funding support. The authors thank Prof. P. V. Satyam, Institute of Physics, Bhubaneswar for the TEM facility. The authors are thankful to Dr Y. S. Chaudhary and K. K. Nanda for the PL facility. RD is thankful to DBT for the Ramalingaswami Fellowship. SM is thankful to DST-INSPIRE-SRF. The authors are also thankful to the Department of Biotechnology, India for funding support.

Funders	Funder number
DST-INSPIRE-SRF
Department of Biotechnology, Ministry of Science and Technology, India
Council of Scientific and Industrial Research, India	P-81-113, MLP-20, CSC-0101, 102/87/2011-NT, Project-YSP-2/2013, 2013/37P/67/BRNS

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1039/c6tb00081a

Cite this

@article{2395f40d8f1a4eef9de339fea5a92270,

title = "Good's buffer derived highly emissive carbon quantum dots: excellent biocompatible anticancer drug carrier",

abstract = "Here, a facile one-step approach has been developed for the synthesis of carbon quantum dots (CQDs) from Good's buffer. The as-synthesized CQDs emit a bright greenish blue coloured fluorescence after exposure to a 365 nm UV-lamp illumination. The bright fluorescence nature of the CQDs has proven them to be excellent probes for cellular imaging. The CQDs are highly biocompatible in nature, which has been validated by an MTT assay test. The in vitro MTT assay demonstrates a more than 95% survival rate when HEK293 (human embryonic kidney) and H357 (human oral squamous carcinoma) cells were treated with CQDs. The low cytotoxicity of Good's buffer derived CQDs opens the door to biomedical applications. The anticancer drug doxorubicin (DOX) was successfully loaded on the CQDs and their delivery efficiency to the target cells via in vitro treatment of cancerous cells was explored. The CQDs supported DOX showed a higher killing rate of the cancer cells compared to bare DOX due to its ease of internalization and efficient pH-triggered release inside the cells.",

author = "Samantara, {Aneeya K.} and Santanu Maji and Arnab Ghosh and Bamaprasad Bag and Rupesh Dash and Jena, {Bikash Kumar}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016.",

year = "2016",

month = apr,

day = "14",

doi = "10.1039/c6tb00081a",

language = "אנגלית",

volume = "4",

pages = "2412--2420",

journal = "Journal of Materials Chemistry B",

issn = "2050-7518",

publisher = "Royal Society of Chemistry",

number = "14",

}

TY - JOUR

T1 - Good's buffer derived highly emissive carbon quantum dots

T2 - excellent biocompatible anticancer drug carrier

AU - Samantara, Aneeya K.

AU - Maji, Santanu

AU - Ghosh, Arnab

AU - Bag, Bamaprasad

AU - Dash, Rupesh

AU - Jena, Bikash Kumar

PY - 2016/4/14

Y1 - 2016/4/14

N2 - Here, a facile one-step approach has been developed for the synthesis of carbon quantum dots (CQDs) from Good's buffer. The as-synthesized CQDs emit a bright greenish blue coloured fluorescence after exposure to a 365 nm UV-lamp illumination. The bright fluorescence nature of the CQDs has proven them to be excellent probes for cellular imaging. The CQDs are highly biocompatible in nature, which has been validated by an MTT assay test. The in vitro MTT assay demonstrates a more than 95% survival rate when HEK293 (human embryonic kidney) and H357 (human oral squamous carcinoma) cells were treated with CQDs. The low cytotoxicity of Good's buffer derived CQDs opens the door to biomedical applications. The anticancer drug doxorubicin (DOX) was successfully loaded on the CQDs and their delivery efficiency to the target cells via in vitro treatment of cancerous cells was explored. The CQDs supported DOX showed a higher killing rate of the cancer cells compared to bare DOX due to its ease of internalization and efficient pH-triggered release inside the cells.

AB - Here, a facile one-step approach has been developed for the synthesis of carbon quantum dots (CQDs) from Good's buffer. The as-synthesized CQDs emit a bright greenish blue coloured fluorescence after exposure to a 365 nm UV-lamp illumination. The bright fluorescence nature of the CQDs has proven them to be excellent probes for cellular imaging. The CQDs are highly biocompatible in nature, which has been validated by an MTT assay test. The in vitro MTT assay demonstrates a more than 95% survival rate when HEK293 (human embryonic kidney) and H357 (human oral squamous carcinoma) cells were treated with CQDs. The low cytotoxicity of Good's buffer derived CQDs opens the door to biomedical applications. The anticancer drug doxorubicin (DOX) was successfully loaded on the CQDs and their delivery efficiency to the target cells via in vitro treatment of cancerous cells was explored. The CQDs supported DOX showed a higher killing rate of the cancer cells compared to bare DOX due to its ease of internalization and efficient pH-triggered release inside the cells.

UR - http://www.scopus.com/inward/record.url?scp=84962707694&partnerID=8YFLogxK

U2 - 10.1039/c6tb00081a

DO - 10.1039/c6tb00081a

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

AN - SCOPUS:84962707694

SN - 2050-7518

VL - 4

SP - 2412

EP - 2420

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 14

ER -

Good's buffer derived highly emissive carbon quantum dots: excellent biocompatible anticancer drug carrier

Abstract

Bibliographical note

Funding

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this