Gonadotrophin releasing hormone (GnRH) was utilized in a dynamic test in 23 women with primary amenorrhea and eight women with secondary amenorrhea in an attempt to localize the site of the primary lesion. In every case the amenorrheic state was due to hypogonadotrophic failure and consequent hypoestrogenism. The pituitary response to a single injection of GnRH was estimated by serial measurements of plasma FSH and LH. Of the 31 women examined, 24 showed a positive response to GnRH stimulation, demonstrating that hypogonadotrophic amenorrhea due to hypothalamic dysfunction is much more frequent than primary pituitary failure. In those cases with a negative pituitary response, the use of additional dynamic tests to clarify the failure of this response are possible. GnRH may also have therapeutic value in hypothalamic hypogonadotrophic states.
|State||Published - 1975|