Golden exosomes: a new platform for cancer theranostics

Adi Anaki, Oshra Betzer, Menachem Motiei, Tamar Sadan, Dror Fixler, Rachela Popovtzer

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Delivery of therapeutics to tumors is a major challenge, due to the sequence of formidable biological barriers in the body and tumor, which limit the penetration of various nano-carriers and drugs into the tumor. Exosomes are promising vectors for delivery of anti-tumor therapies, due to their biocompatibility, ability to evade clearance, and innate ability to home to, and interact with, target cells. However, promoting clinical application of exosome-based therapeutics requires elucidation of key issues, including exosome bio-distribution, tumor targeting, and the ability to overcome tumor barriers. Here, we examined these parameters using mesenchymal stem cell (MSCs)-derived exosomes loaded with gold nanoparticles (GNPs), aiming to delineate design principles for therapy loading and delivery. This novel technology provides essential and fundamental knowledge on exosomes for enhanced targeted drug delivery to tumors, and has potential to promote clinical translation of exosome-based cancer therapy.

Original languageEnglish
Title of host publicationNanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIX
EditorsDror Fixler, Ewa M. Goldys, Sebastian Wachsmann-Hogiu
ISBN (Electronic)9781510648234
StatePublished - 2022
EventNanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIX 2022 - Virtual, Online
Duration: 20 Feb 202224 Feb 2022

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceNanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIX 2022
CityVirtual, Online

Bibliographical note

Publisher Copyright:
Copyright © 2022 SPIE.


  • drug delivery
  • exosomes
  • gold nanoparticles


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