Gold nanorods as absorption contrast agents for the noninvasive detection of arterial vascular disorders based on diffusion reflection measurements

Rinat Ankri, Dorit Leshem-Lev, Dror Fixler, Rachela Popovtzer, Menachem Motiei, Ran Kornowski, Edith Hochhauser, Eli I. Lev

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

In this study we report the use of gold nanorods (GNRs) as absorption contrast agents in the diffusion reflection (DR) method for the in vivo detection of atherosclerotic injury. The early detection and characterization of atherosclerotic vascular disease is considered to be one of the greatest medical challenges today. We show that macrophage cells, which are major components of unstable active atherosclerotic plaques, uptake gold nanoparticles, resulting in a change in the optical properties of tissue-like phantoms and a unique DR profile. In vivo DR measurements of rats that underwent injury of the carotid artery showed a clear difference between the DR profiles of the injured compared with healthy arteries. The results suggest that DR measurements following GNRs administration represent a potential novel method for the early detection of atherosclerotic vascular disease.

Original languageEnglish
Pages (from-to)2681-2687
Number of pages7
JournalNano Letters
Volume14
Issue number5
DOIs
StatePublished - 14 May 2014

Keywords

  • Gold nanoparticles
  • biomolecular imaging
  • gold nanorods
  • macrophages
  • noninvasive detection

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