Gold nanoparticles for safe delivery of cisplatin

Yoray Sharon; Menachem Motiei; Chen Tzror-Azankot; Tamar Sadan; Rachela Popovtzer; Eli Rosenbaum

doi:10.1117/12.3005425

Gold nanoparticles for safe delivery of cisplatin

Yoray Sharon, Menachem Motiei, Chen Tzror-Azankot, Tamar Sadan, Rachela Popovtzer, Eli Rosenbaum

Bar-Ilan University - The Alexander Kofkin Faculty of Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Cisplatin (CP) is the primary standard treatment for bladder cancer. Nevertheless, CP has side effects, particularly nephrotoxicity. This limits the treatment of a notable portion of advanced bladder cancer patients with cisplatin. We have developed gold nanoparticles that conjugate CP (CP-AuNPs) for safer delivery to tumors. Here, we investigated the biodistribution of the CP-AuNP conjugates in a mouse model of bladder cancer, to characterize the distinct role of CPAuNP in delivering and releasing CP in tumor and tissues. Effect of the CP-AuNPs on weight and kidney was also investigated. This study can provide insights into the potential safety of CP-AuNP for bladder cancer treatment.

Original language	English
Title of host publication	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI
Editors	Dror Fixler, Sebastian Wachsmann-Hogiu
Publisher	SPIE
ISBN (Electronic)	9781510669758
DOIs	https://doi.org/10.1117/12.3005425
State	Published - 2024
Event	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI 2024 - San Francisco, United States Duration: 28 Jan 2024 → …

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	12858
ISSN (Print)	1605-7422

Conference

Conference	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI 2024
Country/Territory	United States
City	San Francisco
Period	28/01/24 → …

Bibliographical note

Publisher Copyright:
© COPYRIGHT SPIE. Downloading of the abstract is permitted for personal use only.

Keywords

biodistribution
cancer
cisplatin-gold nanoparticles

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1117/12.3005425

Cite this

Sharon, Y., Motiei, M., Tzror-Azankot, C., Sadan, T., Popovtzer, R., & Rosenbaum, E. (2024). Gold nanoparticles for safe delivery of cisplatin. In D. Fixler, & S. Wachsmann-Hogiu (Eds.), Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI Article 128580D (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 12858). SPIE. https://doi.org/10.1117/12.3005425

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Sharon, Y, Motiei, M, Tzror-Azankot, C, Sadan, T, Popovtzer, R & Rosenbaum, E 2024, Gold nanoparticles for safe delivery of cisplatin. in D Fixler & S Wachsmann-Hogiu (eds), Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI., 128580D, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 12858, SPIE, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI 2024, San Francisco, United States, 28/01/24. https://doi.org/10.1117/12.3005425

Gold nanoparticles for safe delivery of cisplatin. / Sharon, Yoray; Motiei, Menachem; Tzror-Azankot, Chen et al.
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI. ed. / Dror Fixler; Sebastian Wachsmann-Hogiu. SPIE, 2024. 128580D (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 12858).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AB - Cisplatin (CP) is the primary standard treatment for bladder cancer. Nevertheless, CP has side effects, particularly nephrotoxicity. This limits the treatment of a notable portion of advanced bladder cancer patients with cisplatin. We have developed gold nanoparticles that conjugate CP (CP-AuNPs) for safer delivery to tumors. Here, we investigated the biodistribution of the CP-AuNP conjugates in a mouse model of bladder cancer, to characterize the distinct role of CPAuNP in delivering and releasing CP in tumor and tissues. Effect of the CP-AuNPs on weight and kidney was also investigated. This study can provide insights into the potential safety of CP-AuNP for bladder cancer treatment.

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Gold nanoparticles for safe delivery of cisplatin

Abstract

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Bibliographical note

Keywords

UN SDGs

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