Gold nanoparticles for safe delivery of cisplatin

Yoray Sharon, Menachem Motiei, Chen Tzror-Azankot, Tamar Sadan, Rachela Popovtzer, Eli Rosenbaum

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Cisplatin (CP) is the primary standard treatment for bladder cancer. Nevertheless, CP has side effects, particularly nephrotoxicity. This limits the treatment of a notable portion of advanced bladder cancer patients with cisplatin. We have developed gold nanoparticles that conjugate CP (CP-AuNPs) for safer delivery to tumors. Here, we investigated the biodistribution of the CP-AuNP conjugates in a mouse model of bladder cancer, to characterize the distinct role of CPAuNP in delivering and releasing CP in tumor and tissues. Effect of the CP-AuNPs on weight and kidney was also investigated. This study can provide insights into the potential safety of CP-AuNP for bladder cancer treatment.

Original languageEnglish
Title of host publicationNanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI
EditorsDror Fixler, Sebastian Wachsmann-Hogiu
ISBN (Electronic)9781510669758
StatePublished - 2024
EventNanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI 2024 - San Francisco, United States
Duration: 28 Jan 2024 → …

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceNanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI 2024
Country/TerritoryUnited States
CitySan Francisco
Period28/01/24 → …

Bibliographical note

Publisher Copyright:
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  • biodistribution
  • cancer
  • cisplatin-gold nanoparticles


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