Gold nanoparticles for enhanced delivery of chemotherapy

Idan Katzir, Yoray Sharon, Tamar Sadan, Menachem Motiei, Rachela Popovtzer

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review


Chemotherapy is the gold standard for cancer treatment. However, the specific and safe delivery of chemotherapies to cancer cells remains a great challenge. Gold nanoparticles (GNPs) offer a promising solution as carriers for chemotherapy due to their biocompatibility and distinctive physicochemical properties that facilitate precise drug binding and enhanced tumor penetration through the enhanced permeability and retention effect. Here, we have designed GNPs bound to chemotherapies together with glucose coating and studied their cancer cell killing efficacy in a head and neck squamous cell carcinoma cell line. We found that the GNPs bound to chemotherapy had a higher cancer cell killing efficacy as compared to controls, as well as a bystander effect. This GNP-based platform holds promise, for advancing chemotherapy-based cancer treatments.

Original languageEnglish
Title of host publicationNanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI
EditorsDror Fixler, Sebastian Wachsmann-Hogiu
ISBN (Electronic)9781510669758
StatePublished - 2024
EventNanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI 2024 - San Francisco, United States
Duration: 28 Jan 2024 → …

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceNanoscale Imaging, Sensing, and Actuation for Biomedical Applications XXI 2024
Country/TerritoryUnited States
CitySan Francisco
Period28/01/24 → …

Bibliographical note

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  • Cancer
  • chemotherapy
  • gold nanoparticles.


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