Gold nanoparticles based imaging technique and drug delivery for the detection and treatment of atherosclerotic vascular disease

Rinat Ankri; Dorit Leshem-Lev; Eli I. Lev; Menachem Motiei; Edith Hochhauser; Dror Fixler

doi:10.1117/12.2211401

Gold nanoparticles based imaging technique and drug delivery for the detection and treatment of atherosclerotic vascular disease

Rinat Ankri
, Dorit Leshem-Lev
, Eli I. Lev
, Menachem Motiei
, Edith Hochhauser
, Dror Fixler

Rabin Medical Center Israel

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Scopus citations

Abstract

In our study we aim to develop a new, simple and non-invasive method to detect and to treat atherosclerosis. We use gold nanoparticles (GNPs) combined with the diffusion reflection (DR) method to demonstrate the detection of vulnerable atherosclerotic plaques. Our method is based on the fact that macrophages are a major component in the vulnerable plaque and are able to uptake metal nanoparticles that can be discovered by the DR system. Moreover, it is well known that high density lipoprotein (HDL) reduces ASVD by inhibiting pro-inflammatory factors, enabling the specific treatment of atherosclerosis.

Original language	English
Title of host publication	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII
Editors	Alexander N. Cartwright, Dan V. Nicolau
Publisher	SPIE
ISBN (Electronic)	9781628419559
DOIs	https://doi.org/10.1117/12.2211401
State	Published - 2016
Event	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII - San Francisco, United States Duration: 15 Feb 2016 → 17 Feb 2016

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	9721
ISSN (Print)	1605-7422

Conference

Conference	Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII
Country/Territory	United States
City	San Francisco
Period	15/02/16 → 17/02/16

Bibliographical note

Publisher Copyright:
© 2016 SPIE.

Keywords

Biomolecular imaging
Gold nano particles uptake
High density lipoprotein
Macrophages
Noninvasive detection

Access to Document

10.1117/12.2211401

Cite this

Ankri, R., Leshem-Lev, D., Lev, E. I., Motiei, M., Hochhauser, E., & Fixler, D. (2016). Gold nanoparticles based imaging technique and drug delivery for the detection and treatment of atherosclerotic vascular disease. In A. N. Cartwright, & D. V. Nicolau (Eds.), Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII Article 97210F (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9721). SPIE. https://doi.org/10.1117/12.2211401

Ankri, Rinat ; Leshem-Lev, Dorit ; Lev, Eli I. et al. / Gold nanoparticles based imaging technique and drug delivery for the detection and treatment of atherosclerotic vascular disease. Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII. editor / Alexander N. Cartwright ; Dan V. Nicolau. SPIE, 2016. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

@inproceedings{1715e4e3bcce49f1a7d7b4078cd8c02c,

title = "Gold nanoparticles based imaging technique and drug delivery for the detection and treatment of atherosclerotic vascular disease",

abstract = "In our study we aim to develop a new, simple and non-invasive method to detect and to treat atherosclerosis. We use gold nanoparticles (GNPs) combined with the diffusion reflection (DR) method to demonstrate the detection of vulnerable atherosclerotic plaques. Our method is based on the fact that macrophages are a major component in the vulnerable plaque and are able to uptake metal nanoparticles that can be discovered by the DR system. Moreover, it is well known that high density lipoprotein (HDL) reduces ASVD by inhibiting pro-inflammatory factors, enabling the specific treatment of atherosclerosis.",

keywords = "Biomolecular imaging, Gold nano particles uptake, High density lipoprotein, Macrophages, Noninvasive detection",

author = "Rinat Ankri and Dorit Leshem-Lev and Lev, \{Eli I.\} and Menachem Motiei and Edith Hochhauser and Dror Fixler",

note = "Publisher Copyright: {\textcopyright} 2016 SPIE.; Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII ; Conference date: 15-02-2016 Through 17-02-2016",

year = "2016",

doi = "10.1117/12.2211401",

language = "אנגלית",

series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",

publisher = "SPIE",

editor = "Cartwright, \{Alexander N.\} and Nicolau, \{Dan V.\}",

booktitle = "Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII",

address = "ארצות הברית",

}

Ankri, R, Leshem-Lev, D, Lev, EI, Motiei, M, Hochhauser, E & Fixler, D 2016, Gold nanoparticles based imaging technique and drug delivery for the detection and treatment of atherosclerotic vascular disease. in AN Cartwright & DV Nicolau (eds), Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII., 97210F, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9721, SPIE, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII, San Francisco, United States, 15/02/16. https://doi.org/10.1117/12.2211401

Gold nanoparticles based imaging technique and drug delivery for the detection and treatment of atherosclerotic vascular disease. / Ankri, Rinat; Leshem-Lev, Dorit; Lev, Eli I. et al.
Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII. ed. / Alexander N. Cartwright; Dan V. Nicolau. SPIE, 2016. 97210F (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9721).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Gold nanoparticles based imaging technique and drug delivery for the detection and treatment of atherosclerotic vascular disease

AU - Ankri, Rinat

AU - Leshem-Lev, Dorit

AU - Lev, Eli I.

AU - Motiei, Menachem

AU - Hochhauser, Edith

AU - Fixler, Dror

PY - 2016

Y1 - 2016

N2 - In our study we aim to develop a new, simple and non-invasive method to detect and to treat atherosclerosis. We use gold nanoparticles (GNPs) combined with the diffusion reflection (DR) method to demonstrate the detection of vulnerable atherosclerotic plaques. Our method is based on the fact that macrophages are a major component in the vulnerable plaque and are able to uptake metal nanoparticles that can be discovered by the DR system. Moreover, it is well known that high density lipoprotein (HDL) reduces ASVD by inhibiting pro-inflammatory factors, enabling the specific treatment of atherosclerosis.

AB - In our study we aim to develop a new, simple and non-invasive method to detect and to treat atherosclerosis. We use gold nanoparticles (GNPs) combined with the diffusion reflection (DR) method to demonstrate the detection of vulnerable atherosclerotic plaques. Our method is based on the fact that macrophages are a major component in the vulnerable plaque and are able to uptake metal nanoparticles that can be discovered by the DR system. Moreover, it is well known that high density lipoprotein (HDL) reduces ASVD by inhibiting pro-inflammatory factors, enabling the specific treatment of atherosclerosis.

KW - Biomolecular imaging

KW - Gold nano particles uptake

KW - High density lipoprotein

KW - Macrophages

KW - Noninvasive detection

UR - https://www.scopus.com/pages/publications/84982179385

U2 - 10.1117/12.2211401

DO - 10.1117/12.2211401

M3 - ???researchoutput.researchoutputtypes.contributiontobookanthology.conference???

AN - SCOPUS:84982179385

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII

A2 - Cartwright, Alexander N.

A2 - Nicolau, Dan V.

PB - SPIE

T2 - Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII

Y2 - 15 February 2016 through 17 February 2016

ER -

Ankri R, Leshem-Lev D, Lev EI, Motiei M, Hochhauser E, Fixler D. Gold nanoparticles based imaging technique and drug delivery for the detection and treatment of atherosclerotic vascular disease. In Cartwright AN, Nicolau DV, editors, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIII. SPIE. 2016. 97210F. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). doi: 10.1117/12.2211401

Gold nanoparticles based imaging technique and drug delivery for the detection and treatment of atherosclerotic vascular disease

Abstract

Publication series

Conference

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this