Abstract
The development of scaffolding materials that recapitulate the cellular microenvironment and provide cells with physicochemical cues is crucial for successfully engineering functional tissues that can aid in repairing damaged organs. The use of gold nanoparticles for tissue engineering and regenerative medicine has raised great interest in recent years. In this mini review, we describe the shape-dependent properties of gold nanoparticles, and their versatile use in creating tunable nanocomposite scaffolds with improved mechanical and electrical properties for tissue engineering. We further describe using gold nanoparticle-integrated scaffolds to achieve improved stem cells proliferation and differentiation. Finally, we discuss the main challenges and prospects for clinical translation of gold nanoparticles-hybrid scaffolds.
| Original language | English |
|---|---|
| Pages (from-to) | 2198-2206 |
| Number of pages | 9 |
| Journal | Nano Letters |
| Volume | 19 |
| Issue number | 4 |
| DOIs | |
| State | Published - 10 Apr 2019 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2019 American Chemical Society.
Funding
T.D. received support from European Research Council Starting Grant 637943, the Slezak Foundation, the Israeli Science Foundation (700/13), the Israel Ministry of Science, Technology and Space (3-12587) and Moxie Foundation.
| Funders | Funder number |
|---|---|
| Israeli Science Foundation | 700/13 |
| Moxie Foundation | |
| Slezak Foundation | |
| Horizon 2020 Framework Programme | |
| European Commission | 637943 |
| Ministry of Science, Technology and Space | 3-12587 |
Keywords
- Gold nanoparticles
- regenerative medicine
- scaffolds
- tissue engineering