Going from social neuroscience to schizophrenia clinical trials

Michael F. Green, David L. Penn

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The goals of the project Social Cognition and Functioning in Schizophrenia (SCAF) were to (1) identify the domains to target from social neuroscience for translation to clinical schizophrenia research, (2) identify the paradigms that represent these domains for which the neural substrates are well documented, (3) adapt these paradigms for use in schizophrenia clinical trials, (4) assess the psychometric properties of these measures, and (5) assess the external validity of these measures. The articles in this theme section present the initial findings from the SCAF project. As more training and psychopharmacological studies evaluate interventions for social cognition, the articles in this theme section are intended to serve as a guide for informed design decisions about possible endpoints in clinical trials.

Original languageEnglish
Pages (from-to)1189-1191
Number of pages3
JournalSchizophrenia Bulletin
Issue number6
StatePublished - Nov 2013
Externally publishedYes


  • Clinical trials
  • Schizophrenia
  • Social cognition
  • Social neuroscience


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