Goblet cell carcinoid of the appendix: Two case reports and a review of the literature

Alejandro Livoff, Noam Asna, Enrique Gallego-Colon, Aner Zeev Daum, Tattiana Harkovsky, Moshe Schaffer

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Goblet cell carcinoid or carcinoma (GCC) is a rare tumor found incidentally during routine management of acute appendicitis. GCCs are more aggressive compared with conventional appendiceal tumors but less aggressive compared with adenocarcinomas, and they often present with serosal and mesoappendiceal involvement. We herein report two cases of acute appendicitis in a 45-year-old female and a 60-year-old male with varied clinical symptoms. Pathological examination of the appendix revealed the presence of adenocarcinoma with goblet cells and a Ki-67 index of 25% (grade 3) and 15% (grade 2), respectively. Subsequent right hemicolectomy was performed according to the current guidelines. No signs of disease recurrence or metastasis were detected during regular follow-up. However, the lack of a standardized classification system for GCC and the discrepancies in specific reliable markers renders their prognostic and predictive value in GCC at diagnosis insufficient. The present study also aimed to address current concerns regarding the diagnosis, treatment and prognosis of GCC, as well as the need to review and update current guidelines. To conclude, proper clinical management and the prediction of outcome for patients with GCC varies according to the classifications or staging criteria used by the clinicians; hence, a review of the current guidelines should be considered.

Original languageEnglish
Pages (from-to)493-497
Number of pages5
JournalMolecular and Clinical Oncology
Issue number5
StatePublished - Nov 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019, Spandidos Publications. All rights reserved.


  • Appendicular carcinoid,appendicular tumor
  • Case report
  • Goblet cell carcinoid
  • Guidelines
  • Neuroendocrine tumor
  • Prognosis


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