TY - JOUR
T1 - Glucose-Responsive Metal–Organic-Framework Nanoparticles Act as “Smart” Sense-and-Treat Carriers,
AU - Chen, Wei-Hai
AU - Luo, Guo-Feng
AU - V'azquez-Gonz'alez, Margarita
AU - Cazelles, R'emi
AU - Sohn, Sung Yang
AU - Nechushtai, Rachel
AU - Mandel, Yossi
AU - Willner, Itamar
PY - 2018
Y1 - 2018
N2 - Zeolitic Zn2+-imidazolate cross-linked framework nanoparticles, ZIF-8 NMOFs, are used as “smart” glucose-responsive carriers for the controlled release of drugs. The ZIF-8 NMOFs are loaded with the respective drug and glucose oxidase (GOx), and the GOx-mediated aerobic oxidation of glucose yields gluconic acid and H2O2. The acidification of the NMOFs' microenvironment leads to the degradation of the nanoparticles and the release of the loaded drugs. In one sense-and-treat system, GOx and insulin are loaded in the NMOFs. In the presence of glucose, the nanoparticles are unlocked, resulting in the release of insulin. The release of insulin is controlled by the concentration of glucose. In the second sense-and-treat system, the NMOFs are loaded with the antivascular endothelial growth factor aptamer (VEGF aptamer) and GOx. In the presence of glucose, the ZIF-8 NMOFs are degraded, leading to the release of the VEGF aptamer, which acts as a potential inhibitor of the angiogenetic regeneration of blood vessels ...,
AB - Zeolitic Zn2+-imidazolate cross-linked framework nanoparticles, ZIF-8 NMOFs, are used as “smart” glucose-responsive carriers for the controlled release of drugs. The ZIF-8 NMOFs are loaded with the respective drug and glucose oxidase (GOx), and the GOx-mediated aerobic oxidation of glucose yields gluconic acid and H2O2. The acidification of the NMOFs' microenvironment leads to the degradation of the nanoparticles and the release of the loaded drugs. In one sense-and-treat system, GOx and insulin are loaded in the NMOFs. In the presence of glucose, the nanoparticles are unlocked, resulting in the release of insulin. The release of insulin is controlled by the concentration of glucose. In the second sense-and-treat system, the NMOFs are loaded with the antivascular endothelial growth factor aptamer (VEGF aptamer) and GOx. In the presence of glucose, the ZIF-8 NMOFs are degraded, leading to the release of the VEGF aptamer, which acts as a potential inhibitor of the angiogenetic regeneration of blood vessels ...,
UR - http://pubs.acs.org/doi/10.1021/acsnano.8b03417,
UR - http://scholar.google.com/scholar?num=3&hl=en&lr=&q=allintitle%3A%20Glucose-Responsive%20Metal%E2%80%93Organic-Framework%20Nanoparticles%20Act%20as%20%E2%80%9CSmart%E2%80%9D%20Sense-and-Treat%20Carriers%2C%20author%3AWei-Hai%20OR%20author%3AChen%20OR%20author%3AGuo-Feng%20OR%20author%3ALuo%20OR%20author%3AMargarita%20OR%20author%3AV%5Cazquez-Gonz%5Calez%20OR%20author%3AR%5Cemi%20OR%20author%3ACazelles%20OR%20author%3ASung%20OR%20author%3AYang%20OR%20author%3ASohn%20OR%20author%3ARachel%20OR%20author%3ANechushtai%20OR%20author%3AYossi%20OR%20author%3AMandel%20OR%20author%3AItamar%20OR%20author%3AWillner&as_ylo=2018&as_yhi=&btnG=Search&as_vis=0
M3 - Article
JO - ACS nano,
JF - ACS nano,
ER -