Glioblastoma Produces Nitric Oxide (NO) In Response to Activation Stimulus

M. Deutsch, E. Afrimzon, Y Shafran, N Zurgil, M Sobolev

Research output: Contribution to journalArticlepeer-review


Glioblastoma is the most common and lethal primary brain tumor in adults. In order to better understand the nature of the lesion, including the multiple roles of its most important signal molecule NO, a more exact tumor structure simulation in vitro is required. The aim of the presented research is to study the relationship between the level of endogenous NO and mitochondrial function in vitro at individual three-dimensional multicellular object resolution. A close positive association has been revealed between endogenous NO production and mitochondrial membrane hyperpolarization that can support the higher intracellular level of energy required for cell activation, proliferation and movement.
Original languageEnglish
Pages (from-to)29-32
Number of pages4
JournalInternational Journal of Advances in Science Engineering and Technology
Issue number4
StatePublished - Oct 2019


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