Abstract
Immunoglobulin genes are rarely considered as disease susceptibility genes despite their obvious and central contributions to immune function. This appears to be a consequence of historical views on antibody repertoire formation that no longer stand, and of difficulties that until recently surrounded the documentation of the suite of antibody genes in any individual. If these important genes are to be accessible to GWAS studies, allelic variation within the human population needs to be better documented, and a curated set of genomic variations associated with antibody genes needs to be formulated. Repertoire studies arising from the COVID-19 pandemic provide an opportunity to meet these needs, and may provide insights into the profound variability that is seen in outcomes to this infection.
| Original language | English |
|---|---|
| Pages (from-to) | 100-108 |
| Number of pages | 9 |
| Journal | Current Opinion in Systems Biology |
| Volume | 24 |
| DOIs | |
| State | Published - Dec 2020 |
Bibliographical note
Publisher Copyright:© 2020 Elsevier Ltd
Funding
G.Y. is partially supported by the Israel Science Foundation ( ISF [832/16] ). C.T.W. is partially supported by grants from the U.S. National Institutes of Health ( R21AI142590 , R24AI138963 , P20GM135004 ).
| Funders | Funder number |
|---|---|
| U.S. National Institutes of Health | R21AI142590, R24AI138963, P20GM135004 |
| Israel Science Foundation | 832/16 |
Keywords
- AIRR-Seq
- Antibody receptor repertoires
- IGHV
- Iimmune receptor genes
- Immunoglobulin
- Rep-Seq
