Abstract
Wilms’ tumor is a pediatric malignancy that is thought to originate from faulty kidney development during the embryonic stage. However, there is a large variation between tumors from different patients in both histology and gene expression that is not well characterized. Here we use a meta-analysis of published microarray datasets to show that Favorable Histology Wilms’ Tumors (FHWT's) fill a triangle-shaped continuum in gene expression space of which the vertices represent three idealized “archetypes”. We show that these archetypes have predominantly renal blastemal, stromal, and epithelial characteristics and that they correlate well with the three major lineages of the developing embryonic kidney. Moreover, we show that advanced stage tumors shift towards the renal blastemal archetype. These results illustrate the potential of this methodology for characterizing the cellular composition of Wilms’ tumors and for assessing disease progression.
Original language | English |
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Pages (from-to) | 871-881 |
Number of pages | 11 |
Journal | Neoplasia (United States) |
Volume | 20 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2018 |
Bibliographical note
Publisher Copyright:© 2018 The Authors
Funding
Funding: T.K., A.T., and I.K. are supported by the Israel Science Foundation (ICORE no. 1902/12 and Grants no. 1634/13 and 2017/13), the Israel Cancer Association (Grant no. 20150911), the Israel Ministry of Health (Grant no. 3–10146), and the EU-FP7 (Marie Curie International Reintegration Grant no. 618592). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Funders | Funder number |
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EU-FP7 | |
Seventh Framework Programme | 618592 |
Israel Cancer Association | 20150911 |
Israel Science Foundation | 2017/13, 1634/13, 1902/12 |
Ministry of Health, State of Israel | 3–10146 |