Abstract
Glucocorticoids and their receptor (GR) have been an important area of research because of their pleiotropic physiological functions and extensive use in the clinic. In addition, the association between GR and glucocorticoids, which is highly specific, leads to rapid nuclear translocation where GR associates with chromatin to regulate gene transcription. This simplified model system has been instrumental for studying the complexity of transcription regulation processes occurring at chromatin. In this review we discuss our current understanding of GR action that has been enhanced by recent developments in genome wide measurements of chromatin accessibility, histone marks, chromatin remodeling and 3D chromatin structure in various cell types responding to glucocorticoids.
| Original language | English |
|---|---|
| Pages (from-to) | 1175-1185 |
| Number of pages | 11 |
| Journal | Protoplasma |
| Volume | 254 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1 May 2017 |
Bibliographical note
Publisher Copyright:© 2016, Springer-Verlag Wien.
Funding
We apologize to those authors whose articles we have not cited due to space constraints. This work is supported by the Israel Science Foundation (grant 748/14), Marie Curie Integration grant (CIG)- FP7-PEOPLE-20013-CIG-618763, the United States-Israel Bi-national Science Foundation (BSF) and I-CORE Program of the Planning and Budgeting Committee, and The Israel Science Foundation grant no. 41/11.
| Funders | Funder number |
|---|---|
| FP7-PEOPLE-20013-CIG-618763 | |
| United States–Israel Bi-National Science Foundation | |
| United States-Israel Binational Science Foundation | |
| Israel Science Foundation | 748/14 |
| Israeli Centers for Research Excellence | 41/11 |
Keywords
- ChIP-seq
- Chromatin
- Chromatin accessibility
- Enhancers
- Glucocorticoid receptor
- Glucocorticoids
- Long-range interactions
- Transcription
- Transcription factor