Genomic effects of glucocorticoids

Ivana Grbesa, Ofir Hakim

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Glucocorticoids and their receptor (GR) have been an important area of research because of their pleiotropic physiological functions and extensive use in the clinic. In addition, the association between GR and glucocorticoids, which is highly specific, leads to rapid nuclear translocation where GR associates with chromatin to regulate gene transcription. This simplified model system has been instrumental for studying the complexity of transcription regulation processes occurring at chromatin. In this review we discuss our current understanding of GR action that has been enhanced by recent developments in genome wide measurements of chromatin accessibility, histone marks, chromatin remodeling and 3D chromatin structure in various cell types responding to glucocorticoids.

Original languageEnglish
Pages (from-to)1175-1185
Number of pages11
JournalProtoplasma
Volume254
Issue number3
DOIs
StatePublished - 1 May 2017

Bibliographical note

Publisher Copyright:
© 2016, Springer-Verlag Wien.

Keywords

  • ChIP-seq
  • Chromatin
  • Chromatin accessibility
  • Enhancers
  • Glucocorticoid receptor
  • Glucocorticoids
  • Long-range interactions
  • Transcription
  • Transcription factor

Fingerprint

Dive into the research topics of 'Genomic effects of glucocorticoids'. Together they form a unique fingerprint.

Cite this