Genomic analysis at the single-cell level

Tomer Kalisky, Paul Blainey, Stephen R. Quake

Research output: Contribution to journalArticlepeer-review

168 Scopus citations

Abstract

Studying complex biological systems such as a developing embryo, a tumor, or a microbial ecosystem often involves understanding the behavior and heterogeneity of the individual cells that constitute the system and their interactions. In this review, we discuss a variety of approaches to single-cell genomic analysis.

Original languageEnglish
Pages (from-to)431-445
Number of pages15
JournalAnnual Review of Genetics
Volume45
DOIs
StatePublished - 2011
Externally publishedYes

Keywords

  • FACS
  • FISH
  • Gene expression
  • QPCR
  • Sequencing
  • Single cell

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