Genomic analysis at the single-cell level

Tomer Kalisky; Paul Blainey; Stephen R. Quake

doi:10.1146/annurev-genet-102209-163607

Genomic analysis at the single-cell level

Tomer Kalisky, Paul Blainey, Stephen R. Quake

Howard Hughes Medical Institute

Research output: Contribution to journal › Article › peer-review

171 Scopus citations

Abstract

Studying complex biological systems such as a developing embryo, a tumor, or a microbial ecosystem often involves understanding the behavior and heterogeneity of the individual cells that constitute the system and their interactions. In this review, we discuss a variety of approaches to single-cell genomic analysis.

Original language	English
Pages (from-to)	431-445
Number of pages	15
Journal	Annual Review of Genetics
Volume	45
DOIs	https://doi.org/10.1146/annurev-genet-102209-163607
State	Published - 2011
Externally published	Yes

Keywords

FACS
FISH
Gene expression
QPCR
Sequencing
Single cell

Access to Document

10.1146/annurev-genet-102209-163607

Cite this

@article{d23eec831b114269a93f61d0a408d32b,

title = "Genomic analysis at the single-cell level",

abstract = "Studying complex biological systems such as a developing embryo, a tumor, or a microbial ecosystem often involves understanding the behavior and heterogeneity of the individual cells that constitute the system and their interactions. In this review, we discuss a variety of approaches to single-cell genomic analysis.",

keywords = "FACS, FISH, Gene expression, QPCR, Sequencing, Single cell",

author = "Tomer Kalisky and Paul Blainey and Quake, {Stephen R.}",

year = "2011",

doi = "10.1146/annurev-genet-102209-163607",

language = "אנגלית",

volume = "45",

pages = "431--445",

journal = "Annual Review of Genetics",

issn = "0066-4197",

publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - Genomic analysis at the single-cell level

AU - Kalisky, Tomer

AU - Blainey, Paul

AU - Quake, Stephen R.

PY - 2011

Y1 - 2011

N2 - Studying complex biological systems such as a developing embryo, a tumor, or a microbial ecosystem often involves understanding the behavior and heterogeneity of the individual cells that constitute the system and their interactions. In this review, we discuss a variety of approaches to single-cell genomic analysis.

AB - Studying complex biological systems such as a developing embryo, a tumor, or a microbial ecosystem often involves understanding the behavior and heterogeneity of the individual cells that constitute the system and their interactions. In this review, we discuss a variety of approaches to single-cell genomic analysis.

KW - FACS

KW - FISH

KW - Gene expression

KW - QPCR

KW - Sequencing

KW - Single cell

UR - http://www.scopus.com/inward/record.url?scp=80755168360&partnerID=8YFLogxK

U2 - 10.1146/annurev-genet-102209-163607

DO - 10.1146/annurev-genet-102209-163607

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 21942365

AN - SCOPUS:80755168360

SN - 0066-4197

VL - 45

SP - 431

EP - 445

JO - Annual Review of Genetics

JF - Annual Review of Genetics

ER -

Genomic analysis at the single-cell level

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this